Abstract
In the recent past, several actions of GABA in the brain have been elucidated. GABA depresses cellular excitability, and increased GABAergic transmission allows control of seizures (Lloyd et al., 1979). The amino acid also plays an important role in modulating extrapyramidal function (Worms et al., 1980, 1982) via control of various neurotransmitter systems in the basal ganglia (Bartholini et al., 1979; Scatton and Bartholini, 1980, 1982; Scatton et al., 1982); accordingly, increased GABAergic transmission has been shown to be of therapeutic benefit in disorders such as neuroleptic-induced tardive dyskinesia or L-DOPA-induced involuntary movements (Bartholini et al., 1979; Morselli et al., 1980; Sevestre et al., 1982).
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Bartholini, G., Scatton, B., Zivkovic, B., Worms, P., Lloyd, K.G. (1983). Antidepressant and potential antimanic actions of GABA receptor agonists. In: Usdin, E., Goldstein, M., Friedhoff, A., Georgotas, A. (eds) Frontiers in Neuropsychiatric Research. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06689-6_15
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