Abstract
Conceptualisation of plasma proteins as a physiological entity was made possible by the prior establishment of two fundamental facts: (1) that proteins are in a dynamic equilibrium with respect to synthesis and catabolism1 and (2) that plasma proteins escape in the extravascular space, from which they recirculate via the lymphatics2–4. As the result of a surge in modelling activity that has followed these discoveries, the mammalian body soon became envisaged as a set of interconnecting tanks (‘compartments’), among which proteins move to and from in a rather inert fashion. Cells played an undistinguished role in this biophysical perpetuum mobile: although they were appreciated as the source of new protein molecules, yet a plasma protein, once secreted, was supposed to remain in the extracellular space until termination of its life span under poorly understood circumstances—presumably because of cellular ingestion. Put in another way, the intracellular space was not considered part of the normal tissue distribution of a plasma protein. (A notable exception to this way of thinking was IgG, which will be dealt with further below.)
Preview
Unable to display preview. Download preview PDF.
References
Schoenheimer, R. (1942). The Dynamic State of Body Constituents, Harvard University Press, Cambridge, Mass.
Fink, R. M., Enns, T., Kimball, C. P., Silberstein, H. E., Bale, W. F., Madden, S. C. and Whipple, G. H. (1944). J. Exp. Med., 73, 124.
Wasserman, K. and Mayerson, H. S. (1951). Am. J. Physiol., 165, 15.
Sterling, K. (1951). J. Clin. Invest., 30, 1228.
Fahey, J. L. and Robinson, A. G. (1963). J. Exp. Med., 118, 845.
Brambell, F. W. R., Hemmings, W. A. and Morris, I. G. (1964). Nature, Lond., 203, 1352.
Jones, E. A. and Waldmann, T. A. (1972). J. Clin. Invest., 51, 2916.
Waldmann, T. A. and Jones, E. A. (1973). In Protein Turnover, Ciba Foundation Symposium 9 (new series) (G. E. W. Wolstenholme and M. O’Connor, Eds.), Associated Scientific Publishers, Amsterdam, p. 5.
Kaplan, J. (1981). Science, N.Y., 212, 14.
Goldstein, J. L. and Brown, M. S. (1974). J. Biol. Chem., 249, 5153.
Brown, M. S. and Goldstein, J. L. (1975). Cell, 6, 307.
Willingham, M. C., Maxfield, F. R. and Pastan, I. (1979). J. Cell Biol., 82, 614.
Willingham, M. C., Maxfield, F. R. and Pastan, I. (1980). J. Histochem. Cytochem., 28, 818.
Dickson, R. B., Willingham, M. C. and Pastan, I. (1981). J. Biol. Chem., 256, 3454.
Mullock, B. M. and Hinton, R. H. (1981). Trends Biochem. Sci., 6, 188.
Schneider, R. J., Kukzycki, A., Jr., Law, S. K. and Atkinson, J. P. (1981). Nature, Lond., 290, 789.
Kino, K., Tsunoo, H., Higa, Y., Takami, M., Hamaguchi, H. and Nakajima, H. (1980). J. Biol. Chem., 255, 9616.
Higa, Y., Oshiro, S., Kino, K., Tsunoo, H. and Nakajima, H. (1981). J. Biol. Chem., 256, 12322.
Weisiger, R., Gollan, J. and Ockner, R. (1981). Science, N.Y., 211, 1048.
Ashwell, G. and Morell, A. G. (1971). In Glycoproteins of Blood Cells and Plasma (G. A. Jamieson and T. J. Greenwalt, Eds.), Lippincott, Philadelphia, p. 173.
Neufeld, E. F. and Ashwell, G. (1980). In The Biochemistry of Glycoproteins and Proteoglycans (W. J. Lennarz, Ed.), Plenum Press, New York, p. 241.
Ashwell, G. and Harford, J. (1982). Ann. Rev. Biochem., 51, 531.
Harford, J. and Ashwell, G. (1982). In The Glycoconjugates (M. Horovitz, Ed.), Academic Press, New York, Vol. 4, p. 27.
Burger, R. L., Schneider, R. J., Mehlman, C. S. and Allen, R. H. (1975). J. Biol. Chem., 250, 7707.
Mullock, B. M., Jones, R. S., Peppard, J. and Hinton, R. H. (1980). FEBS Lett., 120, 278.
Munro, H. N. and Linder, M. C. (1978). Physiol. Rev., 58, 317.
Aisen, P. and Brown, E. B. (1975). In Progress in Hematology, Vol. IX, (E. B. Brown, Ed.), Grune and Stratton, New York, p. 25.
Jandl, J. H. and Katz, J. H. (1963). J. Clin. Invest., 42, 314.
Jandl, J. H., Inman, J. K., Simmons, R. L. and Allen, D. W. (1959). J. Clin. Invest., 38, 161.
Garrett, N. E., Garrett, R. J. and Archdeacon, J. W. (1973). Biochem. Biophys. Res. Commun., 52, 466.
Witt, D. P. and Woodworth, R. C. (1978). Biochemistry, 17, 3913.
Enns, C. A. and Sussman, H. H. (1981). J. Biol. Chem., 256, 9820.
Enns, C. A. and Sussman, H. H. (1981). J Biol. Chem., 256, 12620.
Sullivan, A. L. and Weintraub, L. R. (1978). Blood, 52, 436.
Van der Heul, C., Kroos, M. J. and Van Eijk, H. G. (1978). Biochim. Biophys. Acta, 511, 430.
Light, N. D. (1978). Biochem. Biophys. Res. Commun., 81, 261.
Laurell, C.B. and Morgan, E. H. (1964). Acta Physiol. Scand., 62, 271.
Van Bockxmeer, F. M., Hemmaplardh, D. and Morgan, E. H. (1975). In Proteins of Iron Storage and Transport in Biochemistry and Medicine (R. R. Crichton, Ed.), Elsevier/North-Holland, Amsterdam, p. 111.
Loh, T. T., Higuchi, D. A., Van Bockxmeer, F. M., Smith, C. H. and Brown, E. B. (1980). J. Clin. Invest., 65, 1182.
Wada, H. G., Hass, P. E. and Sussman, H. H. (1979). J. Biol. Chem., 254, 12629.
Hamilton, T. A., Wada, H. G. and Sussman, H. H. (1979). Proc. Natl Acad. Sci. U.S.A., 76, 6406.
Larrick, J. W. and Cresswell, P. (1979). Biochim. Biophys. Acta, 583, 483.
Fernandez-Pol, J. A. and Klos, D. J. (1980). Biochemistry, 19, 3904.
Enns, C. A., Shihdelman, J. E., Tonik, S. E. and Sussman, H. H. (1981). Proc. Natl Acad. Sci. U.S.A., 78, 4222.
Octave, J.-N., Schneider, Y.-J., Crichton, R. R. and Trouet, A. (1982). FEBS Lett., 137, 119.
Takahashi, K. and Tavassoli, M. (1982). Biochim. Biophys. Acta, 685, 6.
Omary, M. B. and Trowbridge, I. S. (1981). J. Biol. Chem., 256, 12888.
Freeman, T. (1962). In Protides of the Biological Fluids 9th Colloquium, Bruges (H. Peeters, Ed.), Elsevier, Amsterdam, p. 213.
Speyer, B. E. and Fielding, J. (1974). Biochim. Biophys. Acta, 332, 192.
Fielding, J. and Speyer, B. E. (1974). Biochim. Biophys. Acta, 363, 387.
Morgan, E. H. and Baker, E. (1969). Biochim. Biophys. Acta, 184, 442.
Morgan, E. H. and Appleton, T. C. (1969). Nature, Lond., 223, 1371.
Hemmaplardh, D. and Morgan, E. H. (1977). Br. J. Haematol., 36, 85.
Martinez-Medellin, J. and Schulman, H. M. (1972). Biochim. Biophys. Acta, 264, 272.
Sly, D. A., Grohlich, D. and Bezkorovainy, A. (1975). Biochim. Biophys. Acta, 385, 36.
Sullivan, A. L., Grasso, J. A. and Weintraub, L. R. (1976). Blood, 47, 133.
Zaman, Z., Heynen, M.-J. and Verwilghen, R. L. (1980). Biochim. Biophys. Acta, 632, 553.
Hemmaplardh, D., Kailis, S. G. and Morgan, E. H. (1974). Br. J. Haematol., 28, 53.
Van Bockxmeer, F. M. and Morgan, E. H. (1979). Biochim. Biophys. Acta, 584, 76.
Loh, T. T., Yeung, Y. G. and Yeung, D. (1977). Biochim. Biophys. Acta, 471, 118.
Octave, J.-N., Schneider, Y.-J., Hoffmann, P., Trouet, A. and Crichton, R. R. (1979). FEBS Lett., 108, 127.
Octave, J.-N., Schneider, Y.-J., Crichton, R. R. and Trouet, A. (1981). Eur. J. Biochem., 115, 611.
Wyllie, J. C. (1977). Br. J. Haematol., 37, 17.
Karin, M. and Mintz, B. (1981). J. Biol. Chem., 256, 3245.
Edwards, C. L. and Hayes, R. L. (1969). J. Nucl. Med., 10, 103.
Sephton, R. G. and Harris, A. W. (1975). J. Natl Cancer Inst., 54, 1263.
Harris, A. W. and Sephton, R. G. (1977). CancerRes., 37, 3634.
Barry, M. (1974). Gut, 15, 411.
Nagarajan, B., Sivaramakishnan, V. M. and Brahmanandam, S. (1964). Biochem. J., 92, 531.
Morton, A., Hamilton, S. M., Ramsden, D. B. and Tavill, A. S. (1976). In Plasma Protein Turnover (R. Bianchi, G. Mariani and A. S. McFarlane, Eds.), Macmillan, London, p. 165.
Zimelman, A. P., Zimmerman, H. J., McLean, R. and Weintraub, L. R. (1977). Gastroenterology, 72, 129.
Gardiner, M. E. and Morgan, E. H. (1974). Aust. J. Exp. Biol. Med. Sci., 52, 723.
Regoeczi, E., Chindemi, P. A., Hatton, M. W. C. and Berry, L. R. (1980). Arch. Biochem. Biophys., 205, 76.
Beamish, M. R., Keay, L., Okigari, T. and Brown, E. B. (1975). Br. J. Haematol., 31, 479.
Grohlich, D., Morley, C. G. D., Miller, R. J. and Bezkorovainy, A. (1977). In Proteins of Iron Metabolism (E. B. Brown, P. Aisen, J. Fielding and R. R. Crichton, Eds.), Grune and Stratton, New York, p. 335.
Carlsen, S. A., Schmell, E., Weigel, P. H. and Roseman, S. (1981). J. Biol. Chem., 256, 8058.
Grohlich, D., Morley, C. G. D. and Bezkorovainy, A. (1979). Int. J. Biochem., 10, 797.
Young, S. P. and Aisen, P. (1980). Biochim. Biophys. Acta, 633, 145.
Milsom, J. P. and Batey, R. G. (1979). Biochem. J., 182, 117.
Baker, E., Vicary, F. R. and Huehns, E. R. (1981). Br. J. Haematol., 47, 493.
Matter, A., Orci, L. and Rouiller, C. (1969). J. Ultrastruct. Res., Suppl. 11, 1.
Jacques, P. J. (1975). In Pathology of Cell Membranes (B. F. Trump and A. U. Arstila, Eds.), Academic Press, New York, Vol. 1, p. 275.
Tolleshaug, H., Chindemi, P. A. and Regoeczi, E. (1981). J. Biol. Chem., 256, 6526.
Bierman, E. L., Stein, O. and Stein, Y. (1974). Circulation Res., 35, 136.
Regoeczi, E., Chindemi, P. A., Debanne, M. T. and Charlwood, P. A. (1982). Proc. Natl Acad. Sci. U.S.A., 79, 2226.
Regoeczi, E. and Hatton, M. W. C. (1980). Am. J. Physiol., 238, R306.
Debanne, M. T. and Regoeczi, E. (1981). J. Biol. Chem., 256, 11266.
Beaufay, H., Jacques, P., Baudhuin, P., Sellinger, O. Z., Berthet, J. and De Duve, C. (1964). Biochem. J., 92, 184.
Debanne, M. T., Evans, W. H., Flint, N. and Regoeczi, E. (1982). Nature, Lond., 298, 398.
Lane, R. S. (1973). Br. J. Haematol., 24, 343.
Harris, D. C. and Aisen, P. (1975). Biochemistry, 14, 262.
Regoeczi, E. (1975). J. Nucl. Biol. Med., 19, 149.
Gordon, A. H. and Louis, L. N. (1963). Biochem. J., 88, 409.
Regoeczi, E., Taylor, P., Hatton, M. W. C., Wong, K.-L. and Koj, A. (1978). Biochem. J., 174, 171.
Jarritt, P. H. and Charlwood, P. A. (1976). Biochim. Biophys. Acta, 453, 319.
Regoeczi, E., Taylor, P., Debanne, M. T., März, L. and Hatton, M. W. C. (1979). Biochem. J., 184, 399.
Baenziger, J. U. and Fiete, D. (1980). Cell, 22, 611.
Roth, T. F. and Porter, K. W. (1964). J. Cell Biol., 20, 313.
Goldstein, J. L., Anderson, R. G. W. and Brown, M. S. (1979). Nature, Lond., 279, 679.
Wall, D. A., Wilson, G. and Hubbard, A. L. (1980). Cell, 21, 79.
Wall, D. A. and Hubbard, A. L. (1981). J. Cell. Biol., 90, 687.
Bretscher, M. S. (1976). Nature, Lond., 260, 21.
Regoeczi, E., Hatton, M. W. C. and Wong, K.-L. (1975). Can. J. Biochem., 53, 1255.
Regoeczi, E., Chindemi, P. A., Debanne, M. T. and Hatton, M. W. C. (1982). J. Biol. Chem., 257, 5431.
Weigel, P. H. (1981). Biochem. Biophys. Res. Commun., 101, 1419.
Bridges, K., Harford, J., Ashwell, G. and Klausner, R. D. (1982). Proc. Natl Acad. Sci. U.S.A., 79, 350.
Regoeczi, E., Debanne, M. T., Hatton, M. W. C. and Koj, A. (1978). Biochim. Biophys. Acta, 541, 372.
Tanabe, T., Pricer, W. E., Jr. and Ashwell, G. (1979). J. Biol. Chem., 254, 1043.
Steer, C. J. and Ashwell, G. (1980). J. Biol. Chem., 255, 3008.
Warren, R. and Doyle, D. (1981). J. Biol. Chem., 256, 1346.
Tycko, B. and Maxfield, F. R. (1982). Cell, 28, 651.
Baenziger, J. U. and Fiete, D. (1982). J. Biol. Chem., 257, 6007.
Kolset, S. O., Tolleshaug, H. and Berg, T. (1979). Exp. Cell Res., 122, 159.
Tolleshaug, H. and Berg, T. (1979). Biochem. Pharmacol., 28, 2919.
Oka, J. and Weigel, P. H. (1980). Fed. Proc., 39, 2616.
Farquhar, M. G. and Palade, G. E. (1981). J. Cell Biol., 91, 77s.
Schneider, Y.-J., Tulkens, P., De Duve, C. and Trouet, A. (1979). J. Cell Biol., 82, 466.
Schneider, Y.-J., De Duve, C. and Trouet, A. (1981). J. Cell Biol., 88, 380.
Baenziger, J. U. and Maynard, Y. (1980). J. Biol. Chem., 255, 4607.
Stibler, H. and Borg, S. (1981). Alcoholism: Clin. Exp. Res., 5, 545.
Jakobovits, A. W., Morgan, M. Y. and Sherlock, S. (1979). Digest. Dis. Sci., 24, 305.
Editor information
Editors and Affiliations
Copyright information
© 1984 The contributors
About this chapter
Cite this chapter
Regoeczi, E. (1984). Role of cell-surface receptors in the behaviour in vivo of transferren. In: Mariani, G. (eds) Pathophysiology of Plasma Protein Metabolism. Palgrave, London. https://doi.org/10.1007/978-1-349-06680-3_19
Download citation
DOI: https://doi.org/10.1007/978-1-349-06680-3_19
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-06682-7
Online ISBN: 978-1-349-06680-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)