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Kinetics of apolipoproteins A-I and A-II

  • Chapter
Pathophysiology of Plasma Protein Metabolism

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Abstract

Plasma lipoproteins are a polydisperse collection of particles which range in diameter from 7 to 160 nm. These lipoproteins particles have been classified according to methods of separation1. One system, based on density, divides the lipoproteins into five classes: chylomicrons (ρ < 0.95), very-low-density lipoproteins (VLDL, 0.95 < ρ < 1.006), intermediate-density lipoproteins (IDL, 1.006 < ρ < 1.019), low-density lipoproteins (LDL, 1.019 < ρ < 1.063) and high-density lipoproteins (HDL, 1.063 < ρ < 1.210). Another popular system, based on electrophoretic mobility, divides the lipoproteins into those which remain at the origin (chylomicrons) and those which migrate in the beta region (β-lipoproteins), pre-beta regions (pre-β-lipoproteins) and alpha region (α-lipoproteins). There is a partial correspondence of LDL with β-lipoproteins, of VLDL with pre-β-lipoproteins and of HDL with α-lipoproteins. Each lipoprotein is a macromolecular complex of lipids (including triglyceride, cholesterol, cholesterol ester, phospholipid and others) and apolipoproteins (A-I, A-II, A-IV, B, C-I, C-II, C-III, D, E, F, H), arranged such that the lipoprotein particle is relatively soluble in the aqueous plasma environment.

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Authors
  1. L. Zech
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  2. E. J. Schaefer
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  3. J. C. Osborne Jr
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  4. R. L. Aamodt
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  5. H. B. Brewer Jr
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Editor information

Editors and Affiliations

  1. CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy

    Giuliano Mariani

  2. Fifth Medical Pathology, University of Pisa, Pisa, Italy

    Giuliano Mariani

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Zech, L., Schaefer, E.J., Osborne, J.C., Aamodt, R.L., Brewer, H.B. (1984). Kinetics of apolipoproteins A-I and A-II. In: Mariani, G. (eds) Pathophysiology of Plasma Protein Metabolism. Palgrave, London. https://doi.org/10.1007/978-1-349-06680-3_17

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