Abstract
Recent years have witnessed growing interest and intense expectation in the areas of the immunodiagnosis of cancer and the evaluation (both for staging and for monitoring) of cancer patients. This is largely due to recent methodological advances in radioimmunoassay and other immunological techniques that are both highly sensitive and exquisitely specific. The number of tumour markers described in the literature is extremely high, whether this term is restricted to the purely oncodevelopmental, or oncofetal, proteins (those present in the biological fluids of the fetus and of patients with certain forms of cancer, but absent, or in exceedingly low concentrations, in the serum of normal adults) or extended to include the more general definition of tumour-produced, or tumour-related, proteins (such as, for instance, the Bence-Jones proteins of myeloma).
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References
Sullivan, P. W. and Salmon, S. E. (1972). ‘Kinetics of tumour growth and regression in IgG multiple myeloma’. J. Clin. Invest., 51, 1697.
Waldmann, T. A., McIntire, K. R., Dalgard, D. W. and Adamson, R. H. (1976). ‘The metabolism of tumour related proteins’. In Plasma Protein Turnover (R. Bianchi, G. Mariani and A. S. McFarlane, Eds.), Macmillan, London, p. 155.
Viets, D. H., Howards, S. S. and Goldstein, G. (1977). ‘Serum alpha-fetoprotein in testicular tumors’. New Engl. J. Med., 296, 693.
McIntire, K. R., Vogel, C. L., Primack, A., Waldmann, T. A. and Kyalwazi, S. K. (1976). ‘Effect of surgical and chemotherapeutic treatment on alpha-fetoprotein levels in patients with hepatocellular carcinoma’. Cancer, 37, 677.
Waldmann, T. A. and McIntire, K. R. (1979). ‘The use of sensitive assays for alpha-fetoprotein in monitoring the treatment of malignancy’. In Immunodiagnosis of Cancer (R. B. Herberman and K. R. McIntire, Eds.), Marcel Dekker, New York, p. 130.
Vogelzang, N. J., Lange, P. H., Goldman, A., Vessela, R. H., Fraley, E. E. and Kennedy, B. J. (1982). ‘Acute changes of α-fetoprotein and human chorionic gonadotropin during induction chemotherapy of germ cell tumors’. Cancer Res., 42, 4855.
Rioche, M., Quelin, S. and Masseyeff, R. (1974). ‘Synthèse de protéines plasmatiques par les hépatocytes humains cancéreux et normaux en culture’. Pathol. Biol., 22, 867.
Szpirer, C. and Szpirer, J. (1975). ‘A mouse hepatoma cell line which secretes several serum proteins including albumin and α-fetoprotein’. Differentiation, 4, 85.
Kelly, M. G., O’Gara, R. W., Adamson, R. H., Gadekar, K., Botkin, C. D., Reese, W. H., Jr. and Kerber, W. T. (1966). ‘Induction of hepatic cell carcinoma in monkeys with N-nitrosodiethylamine’. J. Natl Cancer Inst., 36, 323.
Sizaret, P. P., McIntire, K. R. and Princler, G. R. (1971). ‘Quantitation of human alpha-fetoprotein by electroimmunodiffusion’. Cancer Res., 31, 1899.
Waldmann, T. A. and McIntire, K. R. (1974). ‘The use of radioimmunoassay for alpha-fetoprotein in the diagnosis of malignancy’. Cancer, 34, 1510.
Berman, M., Shahn, E. and Weiss, M. F. (1962). ‘The routine fitting of kinetic data to models: A mathematical formalism for digital computers’. Biophys. J., 2, 275.
Berman, M. and Weiss, M. F. (1976). SAAM Manual (U.S. DHEW Publication No. NIH 76–730), U.S. Government Printing Office, Washington D.C.
Altman, P. L. (1961). Blood and Other Body Fluids. Biological Handbooks Series, Federation Am. Soc. Exp. Biol., Washington, D.C.
Anderson, W. B. and Pastan, I. (1975). ‘Altered adenylate cyclase activity: its role in growth regulation and transformation of fibroblasts’. In Advances in Nucleotide Research (G. I. Drummond, P. Greengard and G. A. Robinson, Eds.), Raven Press, New York, p. 681.
Pastan, I. H., Johnson, G. S. and Anderson, W. B. (1975). ‘Role of cyclic nucleotides in growth control’. Ann. Rev. Biochem., 44, 491.
Johnson, G. S., Friedman, R. M. and Pastan, I. (1971). ‘Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3’, 5’-cyclic monophosphate and its derivatives. Proc. Natl Acad. Sci. U.S.A., 68, 425.
Willingham, M. C. and Pastan, I. (1975). ‘Cyclic AMP modulates microvillous formation and agglutinability in transformed and normal mouse fibroblasts’. Proc. Natl Acad. Sci. U.S.A., 72, 1263.
Dawe, C. J., Whang-Peng, J., Morgan, W. D., O’Gara, R. W. and Kelly, M. G. (1968). ‘Culture of a cell line (NCLP-6) derived from a hepatocarcinoma induced in Macaca mulatta by N-nitrosodiethylamine’. J. Natl Cancer Inst., 40, 1167.
Setaro, F. and Morley, C. G. D. (1976). ‘A modified fluorometric method for the determination of microgram quantities of DNA from cell or tissue cultures’. Analyt. Biochem., 71, 313.
Gershengorn, M. C., Glinoer, D., Fox, S. H. and Robbins, J. (1976). ‘Thyroxine-binding globulin synthesis by hepatocarcinoma cells in continuous culture: effect of physiological concentrations of thyroxine’. Biochem. Biophys. Res. Commun., 71, 76.
Bélanger, L., Hamel, D., Lachance, L., Dufour, D., Tremblay, M. and Gagnon, P. M. (1975). ‘Hormonal regulation of α1 -fetoprotein’. Nature, Lond., 256, 657.
De Nechaud, B., Becker, J. E. and Potter, V. R. (1976). ‘Effect of glucocorticoids on fetoprotein production by an established cell line from Morris hepatoma 8994’. Biochem. Biophys. Res. Commun., 68, 8.
Isaka, H., Umehara, S. and Tsukada, Y. (1975). ‘α-fetoprotein synthesis in cultured cells: Studies on Yoshida sarcoma and ascites hepatoma in vitro’. Ann N.Y. Acad. Sci., 259, 74.
Tumyan, B. G., Svet-Moldavski, G. G. and Karmanova, N. V. (1975). ‘Factors suppressing α-fetoprotein production in newborn mice’. Nature, Lond., 255, 244.
Kanai, K., Torii, M., Hayashi, S. and Watabe, H. (1979). ‘Effects of cyclic nucleotides on synthesis and release of alpha-fetoprotein by rat ascites hepatoma cells’. In Carcino-Embryonic Proteins (F. G. Lehmann, Ed.), Elsevier/North-Holland, Amsterdam, p. 219.
Bélanger, L., Chiu, J. F., Exton, J. H., Richardson, D., Laberge, C., Larochelle, J. and Bélanger, M. (1979). ‘Relation between ATP and AFP metabolism in liver injuries’. In Carcino-Embryonic Proteins (F. G. Lehmann, Ed.), Elsevier/North-Holland, Amsterdam, Vol. II, p. 223.
Watanabe, A., Miyazaki, M. and Nagashima, H. (1979). ‘Effect of pyridoxine-adenosine 5’-triphosphate and S-adenosylmethionine on increased alpha-fetoprotein synthesis by hepatic injury’. In Carcino-Embryonic Proteins (F. G. Lehmann, Ed.), Elsevier/North-Holland, Amsterdam, Vol. II, p. 231.
Kanai, K., Endo, Y., Oda, T. and Kaneko, Y. (1975). ‘Synthesis of α-fetoprotein by rat ascites hepatoma’. Ann. N.Y. Acad. Sci., 259, 29.
van Vijk, R., Wicks, W. D. and Clay, K. (1972). ‘Effects of derivatives of cyclic 3’, 5’-adenosine monophosphate on the growth, morphology and gene expression of hepatoma cells in culture’. Cancer Res., 32, 1905.
Bélanger, L., Larochelle, J., Bélanger, M. and Privé, L. (1976). ‘Tyrosinosis: Hereditary persistence of alpha1-fetoprotein’. In Onco-Development Gene Expression (W. H. Fishmann and S. Sell, Eds.), Academic Press, New York, p. 155.
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Mariani, G., Sullivan, P.W., McGuire, E.A., McIntire, K.R., Adamson, R.H., Waldmann, T.A. (1984). Significance of in vivo and in vitro metabolic studies of tumour-produced proteins. In: Mariani, G. (eds) Pathophysiology of Plasma Protein Metabolism. Palgrave, London. https://doi.org/10.1007/978-1-349-06680-3_12
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DOI: https://doi.org/10.1007/978-1-349-06680-3_12
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