Benzodiazepine receptor-mediated experimental ‘anxiety’ in rhesus monkeys after infusion of 3-carboethoxy-ß-carboline (ß-CCE)
The presence of specific recognition (viz. receptor) sites for benzodiazepines in brain that are functionally (and perhaps structurally) coupled to both recognition sites for γ-aminobutyric acid (GABA) and a chloride ionophore has been firmly established (cf. Tallman et al., 1980; Paul et al., 1981; Skolnick and Paul, 1982). Both direct and indirect evidence suggest that this ‘supramolecular complex’ mediates the pharmacological actions of benzodiazepines as well as other structurally unrelated compounds which share common properties with the benzodiazepines (Paul et al., 1981; Skolnick and Paul, 1982). Whether this supramolecular complex has a physiological role in the absence of an exogenous ligand (drug) has been a source of considerable speculation, particularly regarding its function in the pathophysiology of anxiety and related disorders (cf. Paul and Skolnick, 1981).
KeywordsRhesus Monkey Plasma Cortisol Acid Ethyl Ester Plasma Cortisol Level Exogenous Ligand
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- File, S. (1982). Animal anxiety and the effects of benzodiazepines. In Pharmacology of Benzodiazepines (ed. S. Paul, P. Skolnick, J. Tallman and E. Usdin), Macmillan, London, in pressGoogle Scholar
- Mendelson, W., Cain, M., Cook, J., Paul, S. and Skolnick, P. (1982). Do benzodiazepine receptors plays a role in sleep regulation: studies with the benzodiazepine antagonist, 3-hydroxymethyl-β-carboline (3-HMC). In Beta-Carbolines and Tetra-isoquinolines (ed. E. Usdin), Alan R. Liss, New York, in pressGoogle Scholar
- Paul, S. and Skolnick, P. (1981). Benzodiazepine receptors and psychopathological states: towards a neurobiology of anxiety. In Anxiety: New Research and Changing Concepts (ed. D. Klein and J. Rabkin), Raven Press, New York, pp. 215–33Google Scholar
- Schweri, M., Cain, M., Cook, J., Paul, S. and Skolnick, P. (1982). Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists Ro 15–1788 and CGS 8216. Pharmacol., Biochem. Behav., in pressGoogle Scholar
- Skolnick, P., Schweri, M., Kutter, E., Williams, E. and Paul, E. (1982). Inhibition of [3H]diazepam and 3-carboethoxy-β-carboline binding by irazepine: evidence for binding to different ‘domains’ of the benzodiazepine receptor. J. Neurochem., in pressGoogle Scholar