Benzodiazepine receptor-mediated experimental ‘anxiety’ in rhesus monkeys after infusion of 3-carboethoxy-ß-carboline (ß-CCE)

  • Steven M. Paul
  • Philip Ninan
  • Thomas Insel
  • Phil Skolnick

Abstract

The presence of specific recognition (viz. receptor) sites for benzodiazepines in brain that are functionally (and perhaps structurally) coupled to both recognition sites for γ-aminobutyric acid (GABA) and a chloride ionophore has been firmly established (cf. Tallman et al., 1980; Paul et al., 1981; Skolnick and Paul, 1982). Both direct and indirect evidence suggest that this ‘supramolecular complex’ mediates the pharmacological actions of benzodiazepines as well as other structurally unrelated compounds which share common properties with the benzodiazepines (Paul et al., 1981; Skolnick and Paul, 1982). Whether this supramolecular complex has a physiological role in the absence of an exogenous ligand (drug) has been a source of considerable speculation, particularly regarding its function in the pathophysiology of anxiety and related disorders (cf. Paul and Skolnick, 1981).

Keywords

Catheter Ethyl Cortisol Epinephrine Catecholamine 

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Copyright information

© The contributors 1983

Authors and Affiliations

  • Steven M. Paul
    • 1
  • Philip Ninan
    • 1
  • Thomas Insel
    • 2
  • Phil Skolnick
    • 3
  1. 1.Clinical Neuroscience BranchNIMH, National Institutes of HealthBethesdaUSA
  2. 2.Clinical Neuropharmacology BranchNIMH, National Institutes of HealthBethesdaUSA
  3. 3.Laboratory of Bioorganic ChemistryNIADDK, National Institutes of HealthBethesdaUSA

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