Antidepressants and components of the beta adrenoceptor system: studies on zimelidine
Treatment of rats with a number of antidepressants for one to several weeks leads to a decrease in the density of beta adrenoceptors in the cerebral cortex and other brain regions (Bergstrom and Kellar, 1979; Maggi et al., 1980). This reduction is accompanied by a concomitant decrease in the beta adrenoceptormediated cyclic AMP accumulation (Vetulani et al., 1976; Wolfe et al., 1978). Similar beta adrenoceptor alterations are also evoked by other antidepressant treatments. Thus, treatment with electro-convulsive therapy and monoamine oxidase inhibitors also induce beta adrenoceptor down-regulation (Gillespie et al., 1979; Sellinger-Barnette et al., 1980). The antidepressant treatments, however, have to be administered for a clinically relevant period of time before the changes are observable, whereas a single treatment does not change the number of beta adrenoceptors nor the associated cyclic AMP accumulation (Sarai et al., 1978; Vetulani et al., 1976; Wolfe et al., 1978).
KeywordsDepression Lithium Cocaine Norepinephrine Catecholamine
Unable to display preview. Download preview PDF.
- Aberg-Wistedt, A., Jostell, K.-G., Ross, S. and Westerlund, D. (1981). Effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression. Psychopharmacology, 74, 297–305CrossRefPubMedGoogle Scholar
- Klysner, R. amd Geisler, A. (1983). Effect of REM sleep deprivation on beta-adrenergic receptors in rat brain. Submitted for publicationGoogle Scholar
- Sugrue, M.F. (1981). Effect of chronic antidepressant administration on rat frontal cortex alpha2- and beta-adrenoceptor binding. Br. J. Pharmacol., 74, 760P–1PGoogle Scholar