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Relationships between receptor affinities of different antidepressants and their clinical profiles

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Clinical Pharmacology in Psychiatry

Abstract

The mechanism of action of antidepressant drugs is not well understood. The classical tricyclic antidepressant drugs as well as some newer antidepressants have been developed as inhibitors of the presynaptical re-uptake of the neurotransmitters norepinephrine (NE) (Glowinski and Axelrod, 1964; Iversen, 1965; Carlsson et al., 1966) and 5-hydroxytryptamine (5-HT) (Carlsson et al., 1969; Ross and Renyi, 1969). It has been hypothesized that the therapeutic action of the antidepressant drugs is due to an increased availability of NE and 5-HT at postsynaptic receptors in the brain as the result of the re-uptake blockade (Schildkraut, 1965; Coppen, 1967; van Praag, 1974). However, in recent years some antidepressants (e.g. mianserin and iprindole) have been developed which lack effect or have only very slight effect on the uptake mechanisms.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Research and Development Laboratories, Astra Läkemedel AB, S-151 85, Södertälje, Sweden

    Hakan Hall

Authors
  1. Hakan Hall
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Editor information

Editors and Affiliations

  1. Department of Clinical Pharmacology, Odense University, School of Medicine, Odense, Denmark

    Lars F. Gram

  2. Department of Psychiatry and Human Behavior, University of California, Irvine, California, USA

    Earl Usdin

  3. Department of Pharmacology, Institute of Medical Biology, University of Tromsø, Tromsø, Norway

    Svein G. Dahl

  4. Department of Psychiatry, Odense University, School of Medicine, Odense, Denmark

    Per Kragh-Sørensen

  5. Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden

    Folke Sjöqvist

  6. L.E.R.S. Sythélabo, Paris, France

    Paolo L. Morselli

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Hall, H. (1983). Relationships between receptor affinities of different antidepressants and their clinical profiles. In: Gram, L.F., Usdin, E., Dahl, S.G., Kragh-Sørensen, P., Sjöqvist, F., Morselli, P.L. (eds) Clinical Pharmacology in Psychiatry. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06671-1_23

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