Significance of the serum lithium concentration and the treatment regimen for wanted and unwanted effects of lithium treatment
Lithium (Li) treatment was the first psychiatric therapy to be monitored through determination of serum concentrations of the drug. In the beginning this served to guard against overdosage and poisoning, but later it was used to ensure sufficient levels for achievement of effect. When Li started being used for prophylactic purposes, i.e. for prevention or alleviation of manic-depressive recurrences, the monitoring procedure became particularly important, because under these circumstances no symptoms were present, and dosage adjustment could therefore not be based on clinical assessment.
KeywordsToxicity Lithium Creatinine Arginine Vasopressin
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