Abstract
Measurement of drugs in saliva has been proposed as a non-invasive means by which serum drug concentrations can be assessed (Horning et al., 1977). The concentrations of many drugs in saliva are equal to or less than the concentrations of free (non-protein-bound) drug in plasma or serum (Horning et al., 1977; Stephen et al., 1980). However, recent studies have shown that neuroleptics such as chlorpromazine (May et al., 1981) and haloperidol (Yamazumi and Miura, 1981) are present in saliva in concentrations exceeding the total plasma concentration of drug.
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Poland, R.E., Rubin, R.T., Friedmann, C.T.H., Kaston, B. (1983). Saliva haloperidol concentrations in schizophrenic patients: relation to serum haloperidol and prolactin concentrations. In: Gram, L.F., Usdin, E., Dahl, S.G., Kragh-Sørensen, P., Sjöqvist, F., Morselli, P.L. (eds) Clinical Pharmacology in Psychiatry. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06671-1_17
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DOI: https://doi.org/10.1007/978-1-349-06671-1_17
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