Targeting of drugs with liposomes

  • G Gregoriadis

Abstract

At least two options are open to us in pursuing optimal drug action (Gregoriadis, 1981a). In the first, creation of specialised molecules, a therapeutically profitable target-drug relationship is usually far from ideal and undesirable side effects are almost always present. In the second, drug molecules that are not necessarily target specific are transported by a carrier to the area of action and subsequently allowed to perform their task. Transport by the carrier should be effected in isolation from the biological space existing between the site of application and the site of action as this would be useful in cases where drugs are either prone to premature excretion and inactivation or detrimental to the non-target space in the host. The carrier itself should be non-toxic, biodegradable and of the appropriate shape and size so as to enable accommodation of a wide variety of therapeutic agents. It should preferably ignore or be ignored by irrelevant (normal) areas and have a pronounced affinity for, and access to the target site within which there should be a mechanism for the release of agents from the carrier. The latter, having accomplished its function, should then be disposed of.

Keywords

Cholesterol Entropy Mercury Methotrexate Microbe 

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Copyright information

© The Contributors 1983

Authors and Affiliations

  • G Gregoriadis
    • 1
  1. 1.Division of Clinical SciencesClinical Research CentreMiddlesexUK

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