Regulation of cell growth by 5’-methylthioadenosine

  • Adolph J Ferro
  • Michael K Riscoe
  • Michael W White

Abstract

The ubiquitous nucleoside 5’-deoxy-5’-methylthioadenosine (MTA) is synthesized from S-adenosylmethionine (SAM) via several metabolic pathways in mammalian cells (Pegg and Hibasami, 1979; Ferro, 1979). MTA, however, does not usually accumulate (normally less than 5 µM, Pegg et al., 1981), but rather is either rapidly degraded to 5-methylthioribose-l-phosphate (MTR-l-P) and adenine by MTA phosphorylase (Pegg and Williams-Ashman, 1969; Garbers, 1978; Ferro et al., 1979) or excreted into the medium in some MTA phosphorylase deficient cell lines (Kamatani and Carson, 1980).

Keywords

Lymphoma Leukemia Adenosine Sarcoma Enzymatic Degradation 

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References

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Copyright information

© The contributors 1982

Authors and Affiliations

  • Adolph J Ferro
    • 1
  • Michael K Riscoe
    • 1
  • Michael W White
    • 1
  1. 1.Department of MicrobiologyOregon State UniversityCorvallisUnited States

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