Selection of mutant murine lymphoid cells partially deficient in S-adenosylhomocysteine hydrolase

  • Naoyuki Kamatani
  • Erik H Willis
  • Dennis A Carson

Abstract

The thioether nucleoside S-adenosylhomocysteine (SAH) is a product and potent natural inhibitor of diverse transmethylation reactions necessary for cell growth and function (Mann et al, 1963; Zappia et al, 1969). SAH does not accumulate in normal cells, but rather is cleaved to adenosine and L-homocysteine by S-adenosylhomocysteine hydrolase (SAHase) (De la Haba et al, 1959; Walker et al, 1975).

Keywords

Toxicity Lymphoma Adenosine Methionine Alkaloid 

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References

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Copyright information

© The contributors 1982

Authors and Affiliations

  • Naoyuki Kamatani
    • 1
  • Erik H Willis
    • 1
  • Dennis A Carson
    • 1
  1. 1.Scripps Clinic and Research FoundationLa JollaUnited States

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