Adenosylmethionine metabolism in mammalian spermatozoa

  • H Guy Williams-Ashman
  • Richard Hatch
  • Jerome Seidenfeld


Over the thirty years since Guilio Cantoni discovered AdoMet, innumerable reactions utilizing this nucleoside have been demonstrated in a huge variety of eukaryotic and prokaryotic cells. It is therefore rather surprising that until quite recently, hardly any consideration was given to AdoMet-dependent processes in higher animal spermatozoa. Reports of the absence of ornithine decarboxylase (Bamberg et al., 1975; Jänne et al., 1973), AdoMet decarboxylase, and spermidine synthase (Jänne et al., 1973) suggested that mammalian sperms are incapable of synthesizing polyamines. Sheid and Wilson (1970) were unable to determine whether bull spermatozoa contained tRNA methyltransferases because of the presence in these cells of a powerful and apparently specific polysaccharide inhibitor of this class of enzymes.


Seminiferous Tubule Seminal Plasma Adenosine Deaminase Epididymal Spermatozoon Sperm Extract 
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© The contributors 1982

Authors and Affiliations

  • H Guy Williams-Ashman
  • Richard Hatch
  • Jerome Seidenfeld

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