Regulatory aspects of S-adenosylmethionine in the periphery and CNS
S-adenosylmethionine (SAM) assumes an active role as a regulator in many biological systems in addition to its role as a cofactor in transmethylation reactions. Our interest in this nucleoside arose as a consequence of studies on the in vivo regulation of the biogenic amine enzymes, phenylethanolamine N-methyltransferase (PNMT) and hydroxyindoleamine O-methyltransferase (HIOMT).
KeywordsHydrolysis Adenosine Dexamethasone Glucocorticoid Methionine
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