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Effects of xylosyladenine and other inhibitors of methylation on induction of murine erythroleukemia cells

  • Charles Garrett
  • Nicholas M Kredich

Abstract

DNA methylation is of undetermined purpose in higher organisms, but a significant body of evidence suggests that it may be involved in cell differentiation (for a recent review see Razin and Riggs, 1980). Several examples have been reported where genes for tissue-specific proteins are less methylated in cells expressing these genes than in cells that do not (Waalwijk and Flavell, 1978; Mandel and Chambon, 1979; McGhee and Ginder, 1979; van der Ploeg and Flavell, 1980; Shen and Maniatis, 1980). Furthermore, some agents that interfere with DNA methylation can also induce differentiation in cultured cells (Christman, 1979; Constantinides et al., 1977, 1978; Christman et al., 1977 Taylor and Jones, 1979; Jones and Taylor, 1980).

Keywords

Pyrimidine Nucleoside Hemoglobin Synthesis Methionine Adenosyltransferase Transmethylation Reaction Murine Erythroleukemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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© The contributors 1982

Authors and Affiliations

  • Charles Garrett
  • Nicholas M Kredich

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