Abstract
Several reactions which take place in the cell change the composition of phospholipid molecules. These reactions which lead to the interconversion of a molecule into another generally take place with the expenditure of low energy levels and are connected with the rearrangement of membrane phospholipids thus contributing to its compositional maintenance and to its functional integrity. It is also now accepted that different tissues and subcellular components possess a typical phsopholipid composition and that many membrane functions require a certain physical state of the membrane which is affected by the interconversion of a lipid molecule into another.
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References
Blusztajn, J.K., Zeisel, S.H., and Wurtman, R.J. (1979). Synthesis of lecithin (phosphatidylcholine) from phosphatidylethanolamine in bovine brain. Brain Res., 179, 319–327.
Blusztajn, J.K., and Wurtman, R.J. (1981). Choline biosynthesis by a preparation enriched in synaptosomes from rat brain. Nature, 290, 417–418.
Bremer, J., and Greenberg, D.M. (1961). Methyltransferring enzyme system of microsomes in the biosynthesis of lecithin. Biochim. Biophys. Acta, 46, 205–216.
Calderini, G., Aldinio, C., Crews, F., Gaiti, A., Scapagnini, U., Algeri, S., Ponzio, F., and Toffano, G. (1981). Aging and information processing. In Apomorphine and other Dopaminomimetics, vol.2:Clinical Pharmacology, (eds. G.U.Corsini and G.L.Gessa), Raven Press, New York.
Crews, F.T., Hirata, F., and Axelrod, J. (1980). Identification and properties of methyltransferases that synthesize phosphatidylcholine in rat brain synaptosomes. J. Neurochem., 35, 1491–1498.
De Medio, G.E., Woelk, H., Gaiti, A., Fratini, F., and Porcellati, G. (1975). The Ca2+ dependent incorporation of nitrogenous bases into brain microsomal phospholipid subspecies in vitro. Ital.J.Biochem., 24, 335–350.
Erbland, J.F., and Marinetti, G.V. (1965). The enzymatic acylation and hydrolysis of lysolecithin. Biochim.Biophys. Acta, 106, 128–138.
Gaiti, A., Goracci, G., De Medio, G.E., and Porcellati, G.(1972). Enzymic synthesis of plasmalogen and O-alkylglycerolipid by base-exchange reaction in the rat brain. Febs Letters, 27, 116–120.
Gaiti, A., Brunetti, M., and Porcellati, G. (1975). The relationships between phospholipid pool and the base-exchange reactions in the Ca2+ stimulated incorporation of ethanolamine into brain microsomal phospholipids. Febs Letters, 49, 361–364.
Goracci, G., Blomstrand, C., Arienti, G., Hamberger, A., and Porcellati, G. (1973). Base-exchange enzymic system for the synthesis of phospholipids in neuronal and glial cells and their subfractions: a possible marker for neuronal membranes. J. Neurochem., 20, 1167–1180.
Hirata, F., and Axelrod, J. (1978). Enzymatic methylation of phosphatidylethanolamine increases erythrocyte membrane fluidity. Nature, 275, 219–220.
Hirata, F., Viveros, O.H., Diliberto, E.J., and Axelrod, J. (1978). Identification and properties of two methyltransferases in the conversion of phosphatidylethanolamine to phosphatidylcholine. Proc. Natl.Acad. Sci., USA, 75, 1718–1721.
Katyal, S.L., and Lombardi, B. (1974). Quantitation of phosphatidyl-N- methyl and N,N-dimethylaminoethanol in liver and lung of N-methylaminoethanol fed rats. Lipids, 9, 81–85.
Kennedy, E.P., and Weiss, S.B. (1956). The function of cytidine coenzymes in the synthesis of phospholipids. J.Biol.Chem., 222, 193–214.
Mozzi, R., and Porcellati, G. (1979). Conversion of phosphatidylethanolamine to phosphatidylcholine in rat brain by the methylation pathway. Febs Letters, 100, 363–366.
Mozzi, R., Andreoli, V., and Porcellati, G. (1980). Involvement of S-adenosylmethionine in brain phospholipid metabolism. In Natural Sulfur Compounds: Novel Biochemical and Structural Aspects, (eds. D. Cavallini, G.E.Gaull and V. Zappia). Plenum Press, New York, pp. 41–54.
Mozzi, R., Siepi, D., Andreoli, V., and Porcellati, G. (1981). The synthesis of choline plasmalogen by the methylation pathway in rat brain. Febs Letters, 131, 115–118.
Porcellati, G., Arienti, G., Pirotta, M., and Giorgini, D. (1971). Base-exchange reactions for the synthesis of phospholipids in nervous tissue: the incorporation of serine and ethanolamine into the phospholipids of isolated brain microsomes. J.Neurochem., 18, 1395–1417.
Skurdal, D.N., and Cornatzer, W.E. (1975). Choline phosphotransferase and phosphatidylethanolamine methyltransferase activities. Int. J. Biochem., 6, 579–583.
Yu, P.H. (1978). Radioenzymatic estimation of S-adenosylmethionine in rat brain regions and subcellular fractions. Anal. Biochem., 86, 498–504.
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Mozzi, R., Siepi, D., Adreoli, V., Porcellati, G. (1982). Conversion of phosphatidylethanolamine to phosphatidylcholine by the methylation pathway in brain, and relation with the membrane structure. In: Biochemistry of S-Adenosylmethionine and Related Compounds. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06343-7_17
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DOI: https://doi.org/10.1007/978-1-349-06343-7_17
Publisher Name: Palgrave Macmillan, London
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