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Central noradrenergic neurons: studies on the mechanism of the in vivo activation of tyrosine hydroxylase

  • Chapter
Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects

Abstract

Neuronal depolarization of peripheral and central catecholamine neurons causes an increase in catecholamine biosynthesis. This enhanced formation of transmitter in both peripheral and central catecholaminergic neurons results from an increase in the apparent activity of the enzyme which is rate-limiting in the formation of catecholamines, tyrosine hydroxylase. However, the precise mechanism whereby the activity of this enzyme is so dramatically increased from one minute to the next during periods of altered impulse flow remains unresolved (Roth et al., 1978; Salzman and Roth, 1979).

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Author information

Authors and Affiliations

  1. Departments of Pharmacology and Psychiatry, Yale University School of Medicine New Haven, CT 06510, USA

    K Gysling & R H Roth

Authors
  1. K Gysling
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  2. R H Roth
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Editor information

Editors and Affiliations

  1. National Institute of Mental Health, USA

    Earl Usdin

  2. University of Colorado, USA

    Norman Weiner

  3. Technion Faculty of Medicine, USA

    Moussa B. H. Youdim

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© 1981 The Contributors

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Gysling, K., Roth, R.H. (1981). Central noradrenergic neurons: studies on the mechanism of the in vivo activation of tyrosine hydroxylase. In: Usdin, E., Weiner, N., Youdim, M.B.H. (eds) Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06276-8_9

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