Phenolsulphotransferase and its clinical importance

  • M. Sandler
  • Glen Rein
  • Vivette Glover
  • Susan M. Bonham Carter
  • Julia Littlewood

Abstract

The sulphotransferases are a large group of enzymes which transfer sulphate to a broad variety of different substrates, acting by the same general mechanism. Phenolsulphotransferase (PST; EC.2.8.2.1) (Gregory and Lipmann, 1957) is typical of this group in that it catalyzes the transfer of sulphate from a donor, 3’-phosphoadenosine 5’-phosphosulphate (PAPS), so called “active sulphate”, to a wide range of phenols.

Keywords

Phenol Dopamine Schizophrenia Neuroblastoma Amphetamine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson, R.J. and Weinshilboum, R.M. (1980). Phenolsulphotransferase in human tissue: radiochemical enzymatic assay and biochemical properties. Clin.Chim.Acta 103, 79–80.CrossRefPubMedGoogle Scholar
  2. Bonham Carter, S.M., Glover, V. and Sandler, M, (1981a). Evidence for separate control of two forms of human platelet phenol sulphotransferase. Submitted for publication.Google Scholar
  3. Bonham Carter, S.M., Glover, V., Sandler, M., Gillmam, P.K. and Bridges, P.K. (1981b). Human platelet phenolsulpho-transferase: characterisation for clinical studies and activity range in depression. Submitted for publication.Google Scholar
  4. Bonham Carter, S.M., Goodwin, B.L., Sandler, M., Gillman, P.K. and Bridges, P.K. (1980a). Decreased conjugated tyramine output in depression: the effect of oral L-cysteine. Br. J. Clin. Pharmac., 10, 305–308.CrossRefGoogle Scholar
  5. Bonham Carter, S.M., Reveley, M.A., Sandler, M., Dewhurst, J., Little, B.C., Hayworth, J. and Priest, R.G. (1980b). Decreased urinary output of conjugated tyramine is associated with lifetime vulnerability to depressive illness. Psychiat. Res., 3, 13–21.CrossRefGoogle Scholar
  6. Bonham Carter, S., Sandler, M., Goodwin, B.L., Sepping, P. and Bridges, P.K. (1978). Decreased urinary output of tyramine and its metabolites in depression. Br. J. Psychiat., 132, 125–132.CrossRefGoogle Scholar
  7. Bonham Carter, S.M., Youdim, M.B.H., Sandler, M., Hunter, K.R. and Stern, G.M. (1974). Enhanced tyramine conjugation in Parkinson’s disease. Clin.Chim.Acta 51, 327–329.CrossRefGoogle Scholar
  8. Bronaugh, R.L., Hattox, S.E., Hoehn, M.M., Murphy, R.C. and Rutledge, C.O. (1975a). The separation and identification of dopamine 3-O-sulphate and dopamine 4-O-sulphate in urine of parkinsonian patients. J. Pharmac. Exp. Ther., 195, 441–452.Google Scholar
  9. Bronaugh, R.L., McMurtry, R.J., Hoehn, M.M. and Rutledge, C.O. (1975b). Conjugation of L-dopa and its metabolites after oral and intravenous administration to parkinsonian patients. Biochem. Pharmac., 24, 1317–1320.CrossRefGoogle Scholar
  10. Caldwell, J. (1976). The metabolism of amphetamines in mammals. Drug Metab. Rev., 4, 219–280.CrossRefGoogle Scholar
  11. Caldwell, J. (1980). Comparative aspects of detoxication in mammals. In Enzymatic Basis of Detoxication, Vol. 1 (ed. W.B. Jakoby), Academic Press, New York, pp. 85–114.Google Scholar
  12. Crowley, T.J., Hoehn, M.M., Rutledge, C.O., Stallings, M.A., Heaton, R.K., Sundell, S. and Stilson, D. (1978). Dopamine excretion and vulnerability to drug-induced parkinsonism. Arch.Gen.Psychiat., 35, 97–104.CrossRefPubMedGoogle Scholar
  13. Glover, V., Bonham Carter, S.M., Sandler, M., Kauffman, H., Burnstock, G., Gillman, P.K. and Bridges, P.K. (1981a). Whole blood ATP in depression. In preparation.Google Scholar
  14. Glover, V., Peatfield, R., Zammit-Pace, R., Littlewood, J., Gawel, M., Rose, F.C. and Sandler, M. (1981d). Platelet monoamine oxidase activity and headache. Submitted for publication.Google Scholar
  15. Glover, V., Sandler, M., Grant, E., Rose, F.C., Orton, D., Wilkinson, M. and Stevens, D. (1977). Transitory decrease in platelet monoamine oxidase activity during migraine attacks. Lancet i, 391–393.CrossRefGoogle Scholar
  16. Glover, V., Sandler, M., Lees, A. and Stern, G. (1981c). Platelet phenolsulphotransferase activity in Parkinson’s disease. In preparation.Google Scholar
  17. Glover, V., Sandler, M., Rein, G., Stern, G. (1981b). Monoamine oxidase and phenolsulphotransferase in Parkinson’s disease. In Progress in Parkinsons Disease, (eds. F. Clifford Rose and R. Capildeo), Pitman Medical, London. In press.Google Scholar
  18. Gregory, J.D. and Lipmann, F. (1957). The transfer of sulfate among phenolic compounds with 3’,5’-diphosphoadenosine as coenzyme. J.Biol.Chem., 229, 1081–1090.Google Scholar
  19. Hart, R.F., Renskers, K.J., Nelson, E.B. and Roth, J.A. (1979). Localization and characterization of phenol sulphotransferase in human platelets. Life Sci., 24, 125–130.CrossRefGoogle Scholar
  20. Levy, G. and Matsuzawa, T. (1967). Pharmacokinetics of salicylamide elimination in man. J.Pharmac.Exp. Ther., 156, 285–293.Google Scholar
  21. Littlewood, J., Glover, V., Peatfield, R. and Sandler, M. (1981). Platelet phenolsulphotransferase activity in headache patients. In preparation.Google Scholar
  22. Mulder, G.J. and Scholtens, E. (1977). Phenolsulphotransferase and uridine diphosphate glucuronyltransferase from rat liver in vivo and in vitro. Biochem. J., 165, 553–559.CrossRefPubMedPubMedCentralGoogle Scholar
  23. Rein, G., Glover, V. and Sandler, M. (1981a). Sulphate conjugation of biologically active monoamines and their metabolites by human platelet phenolsulphotransferase. Clin.Chim.Acta. In press.Google Scholar
  24. Rein, G., Glover, V. and Sandler, M. (1981b). Two forms of phenolsulphotransferase in human platelet and brain: selective inhibition by dichloronitrophenol. Submitted for publication.Google Scholar
  25. Rein, G., Glover, V. and Sandler, M. (1981c). Properties of phenolsulphotransferase M and P in different human tissues. In preparation.Google Scholar
  26. Rein, G. and Sandler, M. (1981). Sulphate conjugation of monoamines and their metabolites in neural crest tumours. In preparation.Google Scholar
  27. Richter, D. (1940). The inactivation of adrenaline in vivo in man. J. Physiol., 98, 361–374.CrossRefGoogle Scholar
  28. Sandler, M. (1978). Implications of the platelet monoamine oxidase deficit during migraine attacks. Res. Clin. Stud. Headache, 6, 65–72.Google Scholar
  29. Sandler, M., Bonham Carter, S., Cuthbert, M.F. and Pare, C.M.B. (1975). Is there an increase in monoamine oxidase activity in depressive illness? Lancet, i, 1045–1049.CrossRefGoogle Scholar

Copyright information

© The Contributors 1981

Authors and Affiliations

  • M. Sandler
    • 1
  • Glen Rein
    • 1
  • Vivette Glover
    • 1
  • Susan M. Bonham Carter
    • 1
  • Julia Littlewood
    • 1
  1. 1.Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics & GynaecologyQueen Charlotte’s HospitalLondonUnited Kingdom

Personalised recommendations