Abstract
The sulphotransferases are a large group of enzymes which transfer sulphate to a broad variety of different substrates, acting by the same general mechanism. Phenolsulphotransferase (PST; EC.2.8.2.1) (Gregory and Lipmann, 1957) is typical of this group in that it catalyzes the transfer of sulphate from a donor, 3’-phosphoadenosine 5’-phosphosulphate (PAPS), so called “active sulphate”, to a wide range of phenols.
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References
Anderson, R.J. and Weinshilboum, R.M. (1980). Phenolsulphotransferase in human tissue: radiochemical enzymatic assay and biochemical properties. Clin.Chim.Acta 103, 79–80.
Bonham Carter, S.M., Glover, V. and Sandler, M, (1981a). Evidence for separate control of two forms of human platelet phenol sulphotransferase. Submitted for publication.
Bonham Carter, S.M., Glover, V., Sandler, M., Gillmam, P.K. and Bridges, P.K. (1981b). Human platelet phenolsulpho-transferase: characterisation for clinical studies and activity range in depression. Submitted for publication.
Bonham Carter, S.M., Goodwin, B.L., Sandler, M., Gillman, P.K. and Bridges, P.K. (1980a). Decreased conjugated tyramine output in depression: the effect of oral L-cysteine. Br. J. Clin. Pharmac., 10, 305–308.
Bonham Carter, S.M., Reveley, M.A., Sandler, M., Dewhurst, J., Little, B.C., Hayworth, J. and Priest, R.G. (1980b). Decreased urinary output of conjugated tyramine is associated with lifetime vulnerability to depressive illness. Psychiat. Res., 3, 13–21.
Bonham Carter, S., Sandler, M., Goodwin, B.L., Sepping, P. and Bridges, P.K. (1978). Decreased urinary output of tyramine and its metabolites in depression. Br. J. Psychiat., 132, 125–132.
Bonham Carter, S.M., Youdim, M.B.H., Sandler, M., Hunter, K.R. and Stern, G.M. (1974). Enhanced tyramine conjugation in Parkinson’s disease. Clin.Chim.Acta 51, 327–329.
Bronaugh, R.L., Hattox, S.E., Hoehn, M.M., Murphy, R.C. and Rutledge, C.O. (1975a). The separation and identification of dopamine 3-O-sulphate and dopamine 4-O-sulphate in urine of parkinsonian patients. J. Pharmac. Exp. Ther., 195, 441–452.
Bronaugh, R.L., McMurtry, R.J., Hoehn, M.M. and Rutledge, C.O. (1975b). Conjugation of L-dopa and its metabolites after oral and intravenous administration to parkinsonian patients. Biochem. Pharmac., 24, 1317–1320.
Caldwell, J. (1976). The metabolism of amphetamines in mammals. Drug Metab. Rev., 4, 219–280.
Caldwell, J. (1980). Comparative aspects of detoxication in mammals. In Enzymatic Basis of Detoxication, Vol. 1 (ed. W.B. Jakoby), Academic Press, New York, pp. 85–114.
Crowley, T.J., Hoehn, M.M., Rutledge, C.O., Stallings, M.A., Heaton, R.K., Sundell, S. and Stilson, D. (1978). Dopamine excretion and vulnerability to drug-induced parkinsonism. Arch.Gen.Psychiat., 35, 97–104.
Glover, V., Bonham Carter, S.M., Sandler, M., Kauffman, H., Burnstock, G., Gillman, P.K. and Bridges, P.K. (1981a). Whole blood ATP in depression. In preparation.
Glover, V., Peatfield, R., Zammit-Pace, R., Littlewood, J., Gawel, M., Rose, F.C. and Sandler, M. (1981d). Platelet monoamine oxidase activity and headache. Submitted for publication.
Glover, V., Sandler, M., Grant, E., Rose, F.C., Orton, D., Wilkinson, M. and Stevens, D. (1977). Transitory decrease in platelet monoamine oxidase activity during migraine attacks. Lancet i, 391–393.
Glover, V., Sandler, M., Lees, A. and Stern, G. (1981c). Platelet phenolsulphotransferase activity in Parkinson’s disease. In preparation.
Glover, V., Sandler, M., Rein, G., Stern, G. (1981b). Monoamine oxidase and phenolsulphotransferase in Parkinson’s disease. In Progress in Parkinson’s Disease, (eds. F. Clifford Rose and R. Capildeo), Pitman Medical, London. In press.
Gregory, J.D. and Lipmann, F. (1957). The transfer of sulfate among phenolic compounds with 3’,5’-diphosphoadenosine as coenzyme. J.Biol.Chem., 229, 1081–1090.
Hart, R.F., Renskers, K.J., Nelson, E.B. and Roth, J.A. (1979). Localization and characterization of phenol sulphotransferase in human platelets. Life Sci., 24, 125–130.
Levy, G. and Matsuzawa, T. (1967). Pharmacokinetics of salicylamide elimination in man. J.Pharmac.Exp. Ther., 156, 285–293.
Littlewood, J., Glover, V., Peatfield, R. and Sandler, M. (1981). Platelet phenolsulphotransferase activity in headache patients. In preparation.
Mulder, G.J. and Scholtens, E. (1977). Phenolsulphotransferase and uridine diphosphate glucuronyltransferase from rat liver in vivo and in vitro. Biochem. J., 165, 553–559.
Rein, G., Glover, V. and Sandler, M. (1981a). Sulphate conjugation of biologically active monoamines and their metabolites by human platelet phenolsulphotransferase. Clin.Chim.Acta. In press.
Rein, G., Glover, V. and Sandler, M. (1981b). Two forms of phenolsulphotransferase in human platelet and brain: selective inhibition by dichloronitrophenol. Submitted for publication.
Rein, G., Glover, V. and Sandler, M. (1981c). Properties of phenolsulphotransferase M and P in different human tissues. In preparation.
Rein, G. and Sandler, M. (1981). Sulphate conjugation of monoamines and their metabolites in neural crest tumours. In preparation.
Richter, D. (1940). The inactivation of adrenaline in vivo in man. J. Physiol., 98, 361–374.
Sandler, M. (1978). Implications of the platelet monoamine oxidase deficit during migraine attacks. Res. Clin. Stud. Headache, 6, 65–72.
Sandler, M., Bonham Carter, S., Cuthbert, M.F. and Pare, C.M.B. (1975). Is there an increase in monoamine oxidase activity in depressive illness? Lancet, i, 1045–1049.
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Sandler, M., Rein, G., Glover, V., Bonham Carter, S.M., Littlewood, J. (1981). Phenolsulphotransferase and its clinical importance. In: Usdin, E., Weiner, N., Youdim, M.B.H. (eds) Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06276-8_80
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DOI: https://doi.org/10.1007/978-1-349-06276-8_80
Publisher Name: Palgrave Macmillan, London
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