Neuroleptic drugs modify retinal dopamine containing amacrine cell tyrosine hydroxylase activity

  • Joseph Cohen
  • Norton H Neff


The administration of various neuroleptic drugs results in the activation of retinal tyrosine hydroxylase of dark adapted rats. Kinetic analysis reveals that activation is due to a decrease of the Km of the enzyme for the pteridine cofactor. Thus, the dopaminecontaining amacrine cells of the eye responds to neuroleptic drugs similarly to the dopaminergic system of the striatum.


Tyrosine Hydroxylase Bipolar Cell Amacrine Cell Neuroleptic Drug Excitatory Transmitter 
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Copyright information

© The Contributors 1981

Authors and Affiliations

  • Joseph Cohen
    • 1
  • Norton H Neff
    • 1
  1. 1.Laboratory of Preclinical PharmacologyNational Institute of Mental Health Saint Elizabeths HospitalWashingtonUnited Kingdom

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