Neuroleptic drugs modify retinal dopamine containing amacrine cell tyrosine hydroxylase activity
The administration of various neuroleptic drugs results in the activation of retinal tyrosine hydroxylase of dark adapted rats. Kinetic analysis reveals that activation is due to a decrease of the Km of the enzyme for the pteridine cofactor. Thus, the dopaminecontaining amacrine cells of the eye responds to neuroleptic drugs similarly to the dopaminergic system of the striatum.
KeywordsTyrosine Hydroxylase Bipolar Cell Amacrine Cell Neuroleptic Drug Excitatory Transmitter
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