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Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects pp 3–14Cite as

Palgrave Macmillan

In situ phosphorylation of vas deferens tyrosine hydroxylase during hypogastric nerve stimulation

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Abstract

Increased catecholaminergic activity in vivo, following stress or administration of catecholamine receptor blocking agents, is associated with activation of tyrosine hydroxylase (Zivkovic et al. 1974; Lovenberg and Bruckwick, 1975; Masserano and Weiner, 1979). Stimulation of cate-cholaminergic neurons in vitro in various intact tissue preparations, when these tissues are either exposed to elevated potassium concentrations or subjected to field stimulation or stimulation of the nerves innervating the tissue, is also associated with activation of tyrosine hydroxylase (Morgenroth et al. 1974; Weiner et al. 1977, 1978; Weiner, 1979). In most of the reported studies, the activation of tyrosine hydroxylase is attributable to an enhancement of the affinity of the enzyme for pterin cofactor or a reduction in the affinity of the enzyme for end-product inhibitor.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Colorado School of Medicine Denver, CO 80262, USA

    Norman Weiner, Fu-Li Lee, John Meligeni & A William Tank

Authors
  1. Norman Weiner
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  2. Fu-Li Lee
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  3. John Meligeni
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  4. A William Tank
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Editor information

Editors and Affiliations

  1. National Institute of Mental Health, USA

    Earl Usdin

  2. University of Colorado, USA

    Norman Weiner

  3. Technion Faculty of Medicine, USA

    Moussa B. H. Youdim

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© 1981 The Contributors

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Weiner, N., Lee, FL., Meligeni, J., Tank, A.W. (1981). In situ phosphorylation of vas deferens tyrosine hydroxylase during hypogastric nerve stimulation. In: Usdin, E., Weiner, N., Youdim, M.B.H. (eds) Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06276-8_1

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