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Sulphinpyrazone and Early Post-infarction Arrhythmias

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Early Arrhythmias Resulting from Myocardial Ischaemia

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Abstract

The pyrazolidine derivative sulphinpyrazone has been in clinical use for over 20 years because of its potent uricosuric properties (Burns et al., 1957). In 1962 a study of arteriosclerotic patients by Murphy and Mustard revealed, by chance, that those taking sulphinpyrazone had prolonged platelet survival and reduced platelet turnover; this effect was confirmed by Smythe et al. (1965), who noted also reduced platelet adhesiveness. These findings were demonstrated later to be independent of reductions in uric acid (Mustard et al., 1967). These facts, somewhat expanded, formed the basis for an opportunity directly to affect platelets, pathological processes associated with them and resulting clinical manifestations.

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Authors
  1. R. C. Browning
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Editors and Affiliations

  1. Department of Physiology and Pharmacology, Royal College, University of Strathclyde, Glasgow, Scotland

    James R. Parratt MSc, PhD, DSc, FPS

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Browning, R.C. (1982). Sulphinpyrazone and Early Post-infarction Arrhythmias. In: Parratt, J.R. (eds) Early Arrhythmias Resulting from Myocardial Ischaemia. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06260-7_19

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  • DOI: https://doi.org/10.1007/978-1-349-06260-7_19

  • Publisher Name: Palgrave Macmillan, London

  • Print ISBN: 978-1-349-06262-1

  • Online ISBN: 978-1-349-06260-7

  • eBook Packages: MedicineMedicine (R0)

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