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The Effect of Non-steroidal Anti-inflammatory Drugs and of a Linoleic Acid-rich Diet on Early Arrhythmias Resulting from Myocardial Ischaemia

  • Chapter
Early Arrhythmias Resulting from Myocardial Ischaemia

Abstract

The fact that 50 per cent of deaths due to ischaemic heart disease (IHD) occur before the patients reach hospital emphasises the importance of preventive hospital therapy. Recently, increasing attention has been paid to the non-steroid anti-inflammatory drugs (NSAIDs) as potential cardioprotective agents, although the results of clinical studies have been conflicting. Thus, the Aspirin Myocardial Infarction Study Research Group (1980) found no conclusive evidence for a beneficial effect of long term aspirin against sudden coronary death. Elwood and Sweetnam (1979) observed a 22 per cent decrease in mortality from IHD of patients treated with aspirin, although this difference in mortality between aspirin and control groups was not statistically significant. According to the Anturane Reinfarction Trial (1980), sulphinpyrazone exerts some preventive effect when given early after an acute myocardial infarction. Fatal complications of coronary disease have been reported to decrease by about 25 per cent in the latest report of the Persantine-Aspirin Reinfarction Study Research Group (1980). The significance of this and other similar trials has recently been discussed by Sherry (1980).

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Authors
  1. L. Szekeres
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  2. I. Leprán
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  3. E. Boros
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  4. I. Takáts
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  5. M. Koltai
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Editor information

Editors and Affiliations

  1. Department of Physiology and Pharmacology, Royal College, University of Strathclyde, Glasgow, Scotland

    James R. Parratt MSc, PhD, DSc, FPS

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Szekeres, L., Leprán, I., Boros, E., Takáts, I., Koltai, M. (1982). The Effect of Non-steroidal Anti-inflammatory Drugs and of a Linoleic Acid-rich Diet on Early Arrhythmias Resulting from Myocardial Ischaemia. In: Parratt, J.R. (eds) Early Arrhythmias Resulting from Myocardial Ischaemia. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06260-7_14

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  • DOI: https://doi.org/10.1007/978-1-349-06260-7_14

  • Publisher Name: Palgrave Macmillan, London

  • Print ISBN: 978-1-349-06262-1

  • Online ISBN: 978-1-349-06260-7

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