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Early Arrhythmias Resulting from Acute Myocardial Ischaemia; Possible Role of Cyclic AMP

  • Chapter
Early Arrhythmias Resulting from Myocardial Ischaemia

Abstract

In 1964, Breckenridge showed that global brain ischaemia produced by decapitation caused a rapid increase in cerebral cyclic AMP (cAMP). Later, Wollenberger et al. (1969) found that cAMP also increases in the ischaemic heart. We proposed that this increase of myocardial cAMP might be a critical event in the genesis of ventricular arrhythmias and fibrillation (Podzuweit et al., 1976). Prior to this hypothesis several other metabolic causes of arrhythmias had been suggested, such as the liberation of potassium ions from the heart (Harris et al., 1954), the intracellular accumulation of free fatty acids and fatty acyl CoA (Kurien and Oliver, 1970; Liedtke et al., 1978), lactic acidosis (Wissner, 1974), a decrease in glycolytical ATP production and local (Ebert et al., 1970) and systemic (Clark and Cummings, 1956; Maling and Moran, 1957) catecholamine activity. Some of these hypotheses have been described in earlier chapters.

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Authors
  1. T. Podzuweit
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Editors and Affiliations

  1. Department of Physiology and Pharmacology, Royal College, University of Strathclyde, Glasgow, Scotland

    James R. Parratt MSc, PhD, DSc, FPS

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Podzuweit, T. (1982). Early Arrhythmias Resulting from Acute Myocardial Ischaemia; Possible Role of Cyclic AMP. In: Parratt, J.R. (eds) Early Arrhythmias Resulting from Myocardial Ischaemia. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06260-7_11

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  • DOI: https://doi.org/10.1007/978-1-349-06260-7_11

  • Publisher Name: Palgrave Macmillan, London

  • Print ISBN: 978-1-349-06262-1

  • Online ISBN: 978-1-349-06260-7

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