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Coexistence of neurotransmitter substances in a specifically defined invertebrate neurone

  • Chapter
Co-Transmission

Abstract

Whether some neurones utilise more than one neurotransmitter is a question which has attracted considerable attention in the past ten years (see Burnstock, 1976, 1978; Osborne, 1979, 1981). This interest was sparked off by biochemical studies on isolated invertebrate neurones (Brownstein et al., 1974; Hanley et al., 1974; Osborne, 1977), and also through the development of specific immunohistochemical procedures to visualise transmitter-specific neurones (Chan-Palay et al., 1978; Hökfelt et al., 1977a,b, 1980 see also, chapters 1 and 4). Before this era it was generally accepted that each neurone had the ability to synthesise, store and release only one transmitter substance. This belief, widely known as Dale’s principle, was based on a vast quantity of experimental data but was consistently questioned due to the lack of conclusive proof, for example, the cholingergic link in adrenergic transmission (Burn and Rand, 1965; Koelle, 1962).

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Author information

Authors and Affiliations

  1. Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, OX2 6AW, UK

    Neville N. Osborne

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  1. Neville N. Osborne
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Editors and Affiliations

  1. University Department of Pharmacology, Oxford, UK

    A. C. Cuello

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Osborne, N.N. (1982). Coexistence of neurotransmitter substances in a specifically defined invertebrate neurone. In: Cuello, A.C. (eds) Co-Transmission. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06239-3_9

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