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Co-Transmission pp 189–206Cite as

Palgrave Macmillan

Coexistence of monoamines in peripheral adrenergic neurones

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Abstract

The suggestion that we made in 1968 that noradrenaline and serotonin (5-hydroxytryptamine) were not only present in the same sympathetic fibres innervating the pineal gland of the rat but might also coexist in their storage vesicles (Jaim-Etcheverry and Zieher, 1968b), was received with skepticism and regarded as a curiosity of nature. However, since then the possibility of the coexistence of putative transmitters in neurones has been more seriously considered and experimental evidence supporting that mechanism accumulated over the years. Such data, in addition to its theoretical implications, have been the subject of several review articles and commentaries (Burnstock, 1976, 1978; Osborne, 1979, 1981; Dismukes, 1979). Nowadays, mainly due to the explosive growth of our knowledge about the localisation of various peptides both in the CNS and in the periphery, the coexistence in neurones of several molecules active in cellular communication, is considered to represent an important mechanism in the regulation of that process (Hökfelt et al., 1980a and b). The articles gathered in this volume bear witness to the profound changes that took place in the ideas that prevailed not long ago.

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Authors and Affiliations

  1. Instituto de Biologia Celular, Facultad de Medicina, 2155, Paraguay

    Guillermo Jaim-Etcheverry & Luis Maria Zieher

  2. Instituto de Biologia Celular, Facultad de Medicina, 1121, Buenos Aires, Argentina

    Guillermo Jaim-Etcheverry & Luis Maria Zieher

Authors
  1. Guillermo Jaim-Etcheverry
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  2. Luis Maria Zieher
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Editors and Affiliations

  1. University Department of Pharmacology, Oxford, UK

    A. C. Cuello

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© 1982 The Contributors

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Jaim-Etcheverry, G., Zieher, L.M. (1982). Coexistence of monoamines in peripheral adrenergic neurones. In: Cuello, A.C. (eds) Co-Transmission. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06239-3_8

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