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Coexistence of traditional neurotransmitters with peptides in the mammalian brain: 5-hydroxytryptamine and substance P in the raphe and γ-aminobutyric acid and motilin in the cerebellum

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Abstract

This chapter will deal with two examples of the coexistence of neuroactive substances in single neurones of the mammalian central nervous system: first, the 5-hydroxytryptamine (5-HT; serotonin)-containing neurone in the raphe and other brain stem nuclei that have coexistent substance P; second, the γ-aminobutyric acid (GABA)-containing Purkinje neurones of the cerebellum which have coexistent motilin.

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Authors and Affiliations

  1. Department of Neurobiology, The Harvard Medical School, Boston, Massachusetts, 02115, USA

    Victoria Chan-Palay

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  1. Victoria Chan-Palay
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  1. University Department of Pharmacology, Oxford, UK

    A. C. Cuello

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Chan-Palay, V. (1982). Coexistence of traditional neurotransmitters with peptides in the mammalian brain: 5-hydroxytryptamine and substance P in the raphe and γ-aminobutyric acid and motilin in the cerebellum. In: Cuello, A.C. (eds) Co-Transmission. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06239-3_1

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