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Nematodes in Immunodeprived and Genetically Immunodefective Rodents

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Animal Models in Parasitology

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Abstract

Most of the nematodes that parasitise man or domestic animals are host-specific. The filarial nematodes Wuchereria bancrofti and Onchocerca volvulus, in particular, develop to maturity only in man and some monkeys. Filarial nematodes are usually unable to develop beyond the early 4th larval stage in rats and mice, but the adult stages or microfilariae may persist for some weeks in mice when transplanted from a permissive host. Mice infected in this way have been described as ‘proxy’ hosts (Nelson et al., 1966). Certain nematodes that infect man develop in less common laboratory rodents, such as hamsters (Necator americanus: Sen, 1972) and jirds (Brugia spp: Denham, this volume). Other nematodes will complete only part of their life cycle in rodents — for example, Ascaris, which does not develop much beyond the 3rd larval stage in the lungs and liver of rodents. In contrast, Trichinella spiralis shows little host specificity, infecting man, rats and mice and mammals in general, and is in consequence the most studied of all nematodes.

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Authors and Affiliations

  1. The Wellcome Trust, 1 Park Square West, London, NW1 4LJ, UK

    Bridget M. Ogilvie

  2. Tropical Disease Unit, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, OC3 9DU, UK

    Michele Jungery

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  1. Bridget M. Ogilvie
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  2. Michele Jungery
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Editors and Affiliations

  1. MRC Laboratory Animals Centre, Carshalton, Surrey, UK

    Dawn G. Owen

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Ogilvie, B.M., Jungery, M. (1982). Nematodes in Immunodeprived and Genetically Immunodefective Rodents. In: Owen, D.G. (eds) Animal Models in Parasitology. Palgrave, London. https://doi.org/10.1007/978-1-349-06136-5_9

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