Abstract
During the past 80 years there has been a steady flow of reports comparing various breeds of sheep and cattle, as well as individuals within breeds, in terms of their resistance to gastrointestinal nematodes and trypanosomes. The vast majority indicate that genetic factors play a part in influencing resistance to the parasites concerned. In view of the economic impact of the diseases caused by these parasites, the possibility of improving livestock production by developing genetically resistant animals has aroused considerable interest. This chapter reviews genetic resistance to parasitic infections in cattle and sheep, and includes a discussion of underlying mechanisms, from the standpoint of resistance to the parasites themselves and of resistance to the diseases they produce. An attempt is also made to assess the potential value of resistant livestock against the background of existing methods of parasite control.
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Adams, D. B. (1978). The induction of selective immunological unresponsiveness in cells of blood and lymphoid tissue during primary infection of sheep with the abomasal nematode Haemonchus contortus. Aust. J. exp. Biol. med. Sci., 56, 107–18
Adams, D. B. and Cripps, A. W. (1977). Cellular changes in the intestinal lymph of sheep infected with the enteric nematode Trichostrongylus colubriformis. Aust. J. exp. Biol. med. Sci., 55, 509–22
Agar, N. S., Evans, J. V. and Roberts, J. (1972). Red blood cell potassium and haemoglobin polymorphism in sheep. A review. Anim. Breed. Abstr., 40, 407–36
Akol, G. W. O. and Murray, Max (1981). Early events in the pathogenesis of African trypanosomiasis in cattle. I. The kinetics of development of the localised skin reaction (chancre) which follows the bite of Glossina morsitans morsitans infected with Trypanosoma congolense (in press)
Allonby, E. W. and Urquhart, G. M. (1973). Self-cure of Haemonchus contortus infections under field conditions. Parasitology, 66, 43–53
Allonby, E. W. and Urquhart, G. M. (1976). A possible relationship between haemonchosis and haemoglobin polymorphism in Merino sheep in Kenya. Res. vet. Sci., 20, 212–4
Altaif, K. I. (1975). Genetic resistance to helminth infections in sheep. PhD Thesis, University of Glasgow
Altaif, K. I. and Dargie, J. D. (1978a). Genetic resistance to helminths. The influence of breed and haemoglobin type on the response of sheep to primary infections with Haemonchus contortus. Parasitology, 77, 161–75
Altaif, K. I. and Dargie, J. D. (1978b). Genetic resistance to helminths. The influence of breed and haemoglobin type on the response of sheep to reinfection with Haemonchus contortus. Parasitology, 77, 177–87
Altaif, K. I. and Dargie, J. D. (1978c). Genetic resistance to helminths. Comparison of the development of Ostertagia circumcincta infections in Scottish Blackface sheep of different haemoglobin type. Res. vet. Sci., 24, 391–3
Bangham, A. D. and Blumberg, B. S. (1958). Distribution of electrophoretically different haemoglobins among some cattle breeds of Europe and Africa. Nature, Lond., 181, 1551–2
Bradley, R. E., Radhakrishnan, C. V., Patil-Kulkarni, V. G. and Loggins, P. E. (1973). Responses of Florida Native and Rambouillet lambs exposed to one and two oral doses of Haemonchus contortus. Am. J. vet. Res., 34, 729–35
Chandler, R. L. (1958). Studies on the tolerance of N’dama cattle to trypanosomiasis. J. comp. Path. Ther., 68, 253–60
Cripps, A. W. and Rothwell, T. L. W. (1978). Immune responses of sheep to the parasitic nematode Trichostrongylus colubriformis: Infections in Thiry-Vella loops. Aust. J. exp. Biol. med. Sci., 56, 99–106
Cunningham, M. P. (1966). Immunity in bovine trypanosomiasis. E. Afr. med. J., 43, 394–7
Cuperlovic, K., Altaif, K. I. and Dargie, J. D. (1978). Genetic resistance to helminths: a possible relationship between haemoglobin type and the immune responses of sheep to non-parasitic antigens. Res. vet. Sci., 25, 125–6
Cvetkovic, L. J., Lepojev, Olga and Vulio, I. (1973). Ispitivanje rasne otpornostic cigaje merino prekosa i merino kavkaz prema zeludacno-crevnim strongilidama u prirodnim uslovima infekcije. Vet. Glas., 27, 867–72
Dargie, J. D. (1980a). The pathophysiological effects of gastrointestinal and liver parasites in sheep. In Digestive Physiology and Metabolism in Ruminants (Y. Ruckebusch and P. Thivend, eds), MTP Press Ltd., Lancaster, pp. 349–71
Dargie, J. D. (1980b). Pathophysiology of trypanosomiasis in the bovine. In Isotope and Radiation Research on Animal Diseases and their Vectors, IAEA, Vienna, pp. 121–31
Dargie, J. D. (1981). Blood protein turnover in parasitised ruminants. The influence of host nutrition. In Isotopes and Radiation in Parasitology IV, IAEA, Vienna (in press).
Dargie, J. D. and Allonby, E. W. (1975). Pathophysiology of single and challenge infections of Haemonchus contortus in Merino sheep. Studies on the kinetics of red cell destruction and production with some observations on the ‘self-cure’ phenomenon. Int. J. Parasit., 5, 147–57
Dargie, J. D., Murray, P. K., Murray, Max, Grimshaw, W. R. T. and McIntyre, W. I. M. (1979). Bovine trypanosomiasis: the red cell kinetics of N’dama and Zebu cattle infected with Trypanosoma congolense. Parasitology, 78, 271–86
Desowitz, R. S. (1959). Studies on immunity and host-parasite relationships. I. The immunological response of resistant and susceptible breeds of cattle to trypanosomal challenge. Ann. trop. Med. Parasit., 53, 293–313
Dineen, J. K., Gregg, P. and Lascelles, A. K. (1978). The response of lambs to vaccination at weaning with irradiated Trichostrongylus colubriformis larvae: segregation into ‘responders’ and ‘non-responders’. Int. J. Parasit., 8, 59–63
Dineen, J. K., Gregg, P., Windon, R. G., Donald, A. D. and Kelly, J. D. (1977). The role of immunologically specific and non-specific components of resistance in cross-protection to intestinal nematodes. Int. J. Parasit., 7, 211–5
Dineen, J. K. and Kelly, J. D. (1976). The levels of prostaglandins in the small intestine of rats during primary and secondary infection with Nippostrongylus braziliensis. Int. Archs Allergy appl. Immun., 51, 429–40
Dineen, J. K. and Windon, R. G. (1980a). The effect of sire selection on the response of lambs to vaccination with irradiated Trichostrongylus colubriformis larvae. Int. J. Parasit., 10, 189–96
Dineen, J. K. and Windon, R. G. (1980b). The effect of acquired resistance on adult worms of Trichostrongylus colubriformis in lambs. Int. J. Parasit., 10, 249–53
Doppler, W., Sere, C. and Schreiber, J. (1980). The economics of beef production in various breeds and cross-breeds in Avetonou/Togo. In Trypanotolerance and Animal Production (E. Karbe and E. K. Freitas, eds), Centre de Recherche et d’Elevage Avetonou, Togo (CREAT), pp. 30–49
Duncan, J. L., Smith, W. D. and Dargie, J. D. (1978). Possible relationship of levels of mucosal IgA and serum IgG to immune unresponsiveness of lambs to Haemonchus contortus. Vet. Parasit., 4, 21–7
Evans, J. V. and Blunt, M. H. (1961). Variations in the gene frequencies of potassium and haemoglobin types in Romney Marsh and Southdown sheep established away from their native environment. Aust. J. biol. Sci., 14, 100–8
Evans, J. V., Blunt, M. H. and Southcott, W. H. (1963). The effects of infection with Haemonchus contortus on the sodium and potassium concentrations in the erythrocytes and plasma in sheep of different haemoglobin types. Aust. J. agric. Res., 4, 549–58
Evans, J. V. and Whitlock, J. H. (1964). Genetic relation between maximumv haematocrit values and haemoglobin type in sheep. Science, N.Y., 145, 1318
Finelle, P. (1973). African animal trypanosomiasis: Part IV Economic problems. Wld Anim. Rev., 5, 15–9
French, M. H. (1938). Studies in animal trypanosomiasis. I. Nitrogen and mineral metabolic disturbances induced by Trypanosoma congolense and Trypanosoma brucei. J. Comp. Path., 51, 23–35
Frisch, J. E. (1981). Factors affecting resistance to ecto- and endo-parasites of cattle in tropical areas and the implications for selection. In Isotopes and Radiation in Parasitology IV, IAEA, Vienna, pp. 17–33
Frisch, J. E. and Vercoe, J. E. (1978). Utilising breed differences in growth of cattle in the tropics. Wld Anim. Rev., 25, 8–12
Gordon, H. McL. (1967). Self-cure reaction. In Reaction of the Host to Parasitism (E. J. L. Soulsby, ed.), N. G. Elwert, Universitäts und Verlagsbuchhandlung, Marburg/Lahn, Germany, pp. 174–90
Gray, A. R. and Luckins, A. G. (1980). The initial stage of infection with cyclically-transmitted Trypanosoma congolense in rabbits, calves and sheep. J. comp. Path. Ther., 90, 499–512
Greig, W. A. and McIntyre, W. I. M. (1979). Diurnal variation in rectal temperature of N’dama cattle in the Gambia. Br. vet. J., 135, 113–8
Holmes, P. H. (1980). Vaccination against trypanosomes. In Vaccines against Parasites (A. E. R. Taylor and R. Muller, eds), Blackwell Scientific, London, pp. 75–105
Hudson, K. M. and Terry, R. J. (1979). Immunodepression and the course of infection of a chronic Trypanosoma brucei infection in mice. Parasite Immun., 1, 317–26
ILCA (1979). Trypanotolerant Livestock in West and Central Africa, Vol. 1: General Study. International Livestock Centre for Africa, Addis Ababa
Jarrett, E. E. E. and Urquhart, G. M. (1971). The immune response to nematode infections. Int. Rev. trop. Med., 4, 53–84
Jennings, F. W., Whitelaw, D. D., Holmes, P. H. and Urquhart, G. M. (1978). The susceptibility of strains of mice to infection with Trypanosoma congolense. Res. vet. Sci., 25, 399–400
Jilek, A. F. and Bradley, R. E. (1969). Haemoglobin types and resistance to Haemonchus contortus in sheep. Am. J. vet. Res., 30, 1773–8
Kloosterman, A., Albers, G. A. A. and Van Den Brink, R. (1978). Genetic variation among calves in resistance to nematode parasites. Vet. Parasit., 4, 353–68
Knight, R. A., Vegors, H. H. and Glimp, H. A. (1973). Effects of breed and date of birth of lambs on gastrointestinal nematode infections. Am. J. vet. Res., 34, 323–7
Le Jambre, L. F. (1978). Host genetic factors in helminth control. In The Epidemiology and Control of Gastrointestinal Parasites of Sheep in Australia (A. D. Donald, W. H. Southcott and J. K. Dineen, eds), CSIRO Australia, p. 137
Letteneur, L. (1978). Crossbreeding N’dama and Jersey cattle in Ivory Coast. Wld Anim. Rev., 27, 36–42
Losos, G. and Chouinard, A. (1979). Pathogenicity of Trypanosomes. IDRC, Ottawa
MacAskill, J. A., Holmes, P. H., Jennings, F. W. and Urquhart, G. M. (1981). Immunological clearance of 7 5 Se-labelled Trypanosoma brucei in mice. III. Studies in animals with acute infections. Immunology (in press)
McEwan Jenkinson, D. and Nay, T. (1973). The sweat glands and hair follicles of Asian, African and South American cattle. Aust. J. biol. Sci., 26, 259–75
McFarlane, W. V., Howard, B., Maloiy, G. M. O. and Hopcraft, D. (1972). Tritiated water in field studies of ruminant metabolism in Africa. In Isotope Studies on the Physiology of Domestic Animals, IAEA, Vienna, pp. 82–102
MacLennan, K. J. R. (1974). The epizootiology of tsetse transmitted trypanosomiasis in relation to livestock development and control measures. In Control Programs for Trypanosomes and their Vectors, Rev. Elev. Med. Vet. Pays Trop. Actes du Colloque, Paris, pp. 259–68
Miller, H. R. P. and Nawa, Y. (1979). Immune regulation of intestinal goblet cell differentiation. Specific induction of non-specific protection against helminths? Nouv. Revue fr. hemat., 21, 31–45
Morrison, W. I. and Murray, M. (1979). Trypanosoma congolense: Inheritance of susceptibility to infection in inbred strains of mice. Expl Parasit., 48, 364–74
Morrison, W. I., Roelants, G. E., Mayor-Withey, K. S. and Murray, M. (1978). Susceptibility of inbred strains of mice to Trypanosoma congolense: correlation with changes in spleen lymphocyte populations. Clin. exp. Immun., 32, 25–40
Murray, P. K., Jennings, F. W., Murray, M. and Urquhart, G. M. (1974). The nature of immunosuppression in Trypanosoma brucei infections in mice. II. The role of the T and B lymphocytes. Immunology, 27, 825–40
Murray, M. and Morrison, W. I. (1981). Trypanotolerance. Its basis and future role in animal production in Africa. In Isotopes and Radiation in Parasitology IV, IAEA, Vienna (in press)
Murray, M., Morrison, W. I., Emery, D. L., Akol, G. W. O., Masake, R. A. and Moloo, S. K. (1980). Pathogenesis of trypanosome infections in cattle. In Isotope and Radiation Research on Animal Diseases and their Vectors, IAEA, Vienna, pp. 15–32
Murray, M., Morrison, W. I., Murray, P. K., Clifford, D. J. and Trail, J. C. M. (1979). Trypanotolerance — a review. Wld Anim. Rev., 31, 2–12
Ogilvie, B. M. and Jones, V. E. (1973). Nippostrongylus braziliensis: A review of immunity and the host/parasite relationship in the rat. Expl Parasit., 29, 138–77
O’Kelly, J. C. (1980). Parasitism and blood composition in genetically different types of cattle grazing in a tropical environment. Vet. Parasit., 6, 381–90
Passwell, J. H., Steward, M. W. and Soothill, J. F. (1974). Inter-mouse strain differences in macrophage function and its relationship to antibody responses. Clin. exp. Immun., 17, 159–67
Preston, J. M. and Allonby, E. W. (1978). The influence of breed on the susceptibility of sheep and goats to a single experimental infection of Haemonchus contortus. Vet. Rec., 103, 509–12
Preston, J. M. and Allonby, E. W. (1979a). The influence of breed on the susceptibility of sheep to Haemonchus contortus infection in Kenya. Res. vet. Sci., 26, 134–9
Preston, J. M. and Allonby, E. W. (1979b). The influence of haemoglobin phenotype on the susceptibility of sheep to Haemonchus contortus infection in Kenya. Res. vet. Sci., 26, 140–4
Radhakrishnan, C. V., Bradley, R. E. and Loggins, P. E. (1972). Host responses of worm-free Florida Native and Rambouillet lambs experimentally infected with Haemonchus contortus. Am. J. vet. Res., 33, 817–33
Rifkin, G. G. and Dobson, C. (1979). Predicting resistance of sheep to Haemonchus contortus infections. Vet. Parasit., 5, 365–78
Roberts, C. J. and Gray, A. R. (1973a). Studies on trypanosome-resistant cattle. I. The breeding and growth performance of N’dama, Muturu and Zebu cattle maintained under the same conditions of husbandry. Trop. Anim. Hlth Prod., 5, 211–9
Roberts, C. J. and Gray, A. R. (1973a). Studies on trypanosome resistant cattle. II. The effect of trypanosomiasis on N’dama, Muturu and Zebu cattle. Trop. Anim. Hlth Prod., 5, 220–33
Ross, J. G. (1970). Genetic differences in the susceptibility of sheep to infection with Trichostrongylus axei: A comparison of Scottish Blackface and Dorset breeds. Res. vet. Sci., 11, 465–8
Ross, J. G., Duncan, J. L. and Halliday, W. G. (1978). Investigation of Haemonchus contortus infections in sheep. Comparison of irradiated larvae and transfer factor treatment. Res. vet. Sci., 27, 258–9
Ross, J. G. and Halliday, W. G. (1978). Investigation of the transfer of immunity to gastrointestinal nematode infections in sheep by leucocyte lysates. Vet. Rec., 102, 240–1
Ross, J. G., Lee, R. P. and Armour, J. (1959). Haemonchosis in Nigerian Zebu cattle: the influence of genetical factors in resistance. Vet. Rec., 71, 27–31
Rothwell, T. L. W., Dineen, J. K. and Love, R. J. (1971). The role of pharmacologically-active amines in resistance to Trichostrongylus colubriformis in the guinea pig. Immunology, 21, 925–38
Sacks, D. L., Selkirk, M., Ogilvie, B. M. and Askonas, B. A. (1980). Intrinsic immunosuppressive activity of different trypanosome strains varies with parasite virulence. Nature, Lond., 283, 476–8
Scrivner, L. H. (1964a). Breed resistance to ostertagiasis in sheep. J. Am. vet. med. Ass., 144, 883–7
Scrivner, L. H. (1964b). Transmission of resistance to ovine ostertagiasis. J. Am. vet. med. Ass., 144, 1024–7
Scrivner, L. H. (1967). Genetic resistance to ostertagiasis and haemonchosis in lambs. J. Am. vet. med. Ass., 151, 1443–6
Sinski, E. and Holmes, P. H. (1977). Nippostrongylus brasiliensis: Systemic and local IgA and IgG immunoglobulin responses in parasitised rats. Expl Parasit., 43, 382–9
Smith, W. D. and Christie, M. G. (1978). Haemonchus contortus: local and serum antibodies in sheep immunised with irradiated larvae. Int. J. Parasit., 8, 219–23
Smith, W. D. and Christie, M. G. (1979). Haemonchus contortus: some factors influencing the degree of resistance of sheep immunised with attenuated larvae. J. Comp. Path. Ther., 89, 141–50
Soulsby, E. J. L. and Stewart, D. F. (1960). Serological studies of the self-cure reaction in sheep infected with Haemonchus contortus. Aust. J. agric. Res., 11, 595–603
Stephen, L. E. (1966). Observations on the resistance of West African N’dama and Zebu cattle to trypanosomiasis following challenge by wild Glossina morsitans from an early age. Ann. trop. Med. Parasit., 60, 230–46
Stewart, D. F. (1950). Studies on resistance of sheep to infestation with Haemonchus contortus and Trichostrongylus spp. and on the immunological reactions of sheep exposed to infestation. II. The antibody response to natural infestation in grazing sheep and the self-cure phenomenon. Aust. J. agric. Res., 1, 427–39
Stewart, D. F. (1953). Studies on resistance of sheep to infestation with Haemonchus contortus and Trichostrongylus spp. and on the immunological reactions of sheep exposed to infestation. V. The nature of the self-cure phenomenon. Aust. J. agric. Res., 4, 100–17
Stewart, J. L. (1951). The West African shorthorn cattle: their value to Africa as trypanosomiasis-resistant animals. Vet. Rec., 63, 454–7
Stewart, M. A., Miller, R. F. and Douglas, J. R. (1937). Resistance of sheep of different breeds to infestation by Ostertagia circumcincta. J. agric. Res., 55, 923–30
Terry, R. J., Hudson, K. M., Faghihi-Shirazi, M. and May, D. (1980). Secondary immunodeficiencies associated with African trypanosomiasis. In Isotope and Radiation Research on Animal Diseases and their Vectors, IAEA, Vienna, pp. 133–47
Urquhart, G. M. (1980). Application of immunity in the control of parasitic disease. Vet. Parasit., 6, 217–39
Vercoe, J. E. (1974). Studies on adaptation of cattle to tropical environments and the role of radioisotopes. In Tracer Techniques in Tropical Animal Production, IAEA, Vienna, pp. 73–87
Vickerman, K. (1978). Antigenic variation in trypanosomes. Nature, Lond., 273, 613–7
Wakelin, D. (1978). Genetic control of susceptibility and resistance to parasite infection. Adv. Parasit., 16, 219–308
Wakelin, D. (1981). Mouse models of genetic variation in resistance to helminth parasites (this volume)
Whitlock, J. H. (1955). A study of the inheritance of resistance to trichostrongylidosis in sheep. Cornell Vet., 45, 422–39
Whitlock, J. H. (1958). The inheritance of resistance to trichostrongylidosis in sheep. I. Demonstration of the validity of the phenomenon. Cornell Vet., 48, 127–33
Whitlock, J. H. and Madsen, H. (1958). The inheritance of resistance to trichostrongylidosis in sheep. II. Observations on the genetic mechanisms of trichostrongylidosis. Cornell Vet., 48, 134–45
Willadsen, P. (1980). Immunity to ticks. Adv. Parasit., 18, 293–313
Windon, R. G. and Dineen, J. K. (1981). The effect of selection of both sire and dam on the response of F1 generation lambs to vaccination with irradiated Trichostrongylus colubriformis larvae. Int. J. Parasit., 11, 11–8
Windon, R. G., Dineen, J. K. and Kelly, J. D. (1980). The segregation of lambs into ‘responders’ and ‘non-responders’: response to vaccination with irradiated Trichostrongylus colubriformis larvae before weaning. Int. J. Parasit., 10, 65–73
Yazwinski, T. A., Goode, L., Moncol, D. J., Morgan, G. W. and Linnerud, A. C. (1979). Parasite resistance in straightbred and crossbred Barbados Blackbelly sheep. J. Anim. Sci., 49, 919–26
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Dargie, J.D. (1982). The Influence of Genetic Factors on the Resistance of Ruminants to Gastrointestinal Nematode and Trypanosome Infections. In: Owen, D.G. (eds) Animal Models in Parasitology. Palgrave, London. https://doi.org/10.1007/978-1-349-06136-5_2
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