Characterization of Human Brain Phenol Sulfotransferase
The biogenic amine neurotransmitters are inactivated in the central nervous system by several enzymatic reactions including deamination by monoamine oxidase (MAO), 0-methylation by catechol-0-methyltransferase (COMT) and 0-sulfation by phenol sulfotransferase (PST). The properties and location of both MAO and COMT have been extensively studied in human brain whereas the enzyme or enzymes involved in sulfate conjugation have received relatively little attention. Recent evidence (Anderson and Weinshilboum, 1980; Tyce et al., 1980; Renskers et al., 1980) has suggested that sulfate conjugation may contribute significantly to the overall inactivation of the putative amine neurotransmitters, especially dopamine. However, quantitative information as to the magnitude of this enzymatic process in human brain has not been assessed.
KeywordsHuman Brain Kinetic Constant Total Enzymatic Activity Crude Homogenate COMT Activity
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