Abstract
In mental health research every step in the monoamine metabolism may be of importance. In man the study of the enzymes concerned is hampered because human tissue is not readily available. There is no valid reason to assume identical properties of human and animal enzymes, nor does an animal model exist for mental health research. Therefore, human enzymes derived from readily accessible sites are urgently needed. Phenolsulfotransferase (PST; EC 2.8.2.1), the enzyme responsible for the sulfation of i.a. catechol compounds, has been found in many animal tissues including brain (Eccleston and Ritchie, 1973; Foldes and Meek, 1973, 1974; Jenner and Rose, 1973; Meek and Neff, 1973; Van Kempen et al., 1975; Wong, 1975).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Anderson, R.J. and Weinshilboum, R.M. (1978). Phenolsulphotransferase (PST): presence of enzyme activity and of endogenous inhibitors in the human erythrocyte (RBC). Pharmacologist, 20, 218.
Anderson, R.J. and Weinshilboum, R.M. (1979). Phenolsulphotransferase: enzyme activity and endogenous inhibitors in the human erythrocyte. J. Lab. Clin. Med., 94, 158–171.
Anderson, R.J. and Weinshilboum, R.M. (1980). Phenolsulphotransferase in human tissue: radiochemical enzymatic assay and biochemical properties. Clin. Chim. Acta. 103. 79–90.
Baillie, T.A., Boobis, A.R., Davies, D.S., Frank, H. and Murray, S. (1980). Stereoselective excretion of 3-methoxy-4-hydroxy-phenylethylene glycol sulphate in the dog. Brit. J. Pharmacol., 69, 320–321.
Banerjee, R.K. and Roy, A.B. (1968). Kinetic studies of the phenol sulphotransferase reaction. Biochim. biophys. Acta, 151. 573–586.
Blombery, P.A., Kopin, I.J., Gordon, E.K., Markey, S.P. and Ebert, M.H. (1980). Conversion of MHPG to vanillylmandelic acid. Arch. Gen. Psychiatry, 37, 1095–1098.
Bonham Carter, S.M., Reveley, M.A., Sandler, M., Dewhurst, J., Little, B.C., Hayworth, J. and Priest, R.G. (1980). Decreased urinary output of conjugated tyramine is associated with lifetime vulnerability to depressive illness. Psychiatry Res., 3, 13–21.
Cleland, W.W. (1970). Steady state kinetics. In The Enzymes (ed. P.D. Boyer), vol. II, Academic Press, New York.
Eccleston, D. and Ritchie, I.M. (1973). Sulphate ester formation from catecholamine metabolites and pyrogallol in rat brain in vivo. J. Neurochem., 21, 635–64.
Foldes, A. and Meek, J.L. (1973). Rat brain phenolsulfotransferase — partial purification and some properties. Biochim. biophys. Acta. 327, 365–373.
Foldes, A. and Meek, J.L. (1974). Occurrence and localization of brain phenolsulphotransferase. J. Neurochem., 23, 303–307.
Hart, R.F., Renskers, K.J., Nelson, E.B. and Roth, J.A. (1979). Localization and characterization of phenol sulfotransferase in human platelets. Life Sci., 24, 125–130.
Jenner, W.N. and Rose, F.A. (1973). Studies on sulphation of 3,4-dihydroxyphenylethylamine (dopamine) and related com-pounds by rat tissues. Biochem. J., 135, 109–114.
Jenner, W.N. and Rose, F.A. (1978). Dopamine 3- and 4–0-1-[35s]sulphates as substrates for arylsulphatases in vitro and their metabolism by the rat in vivo. In Conjugation Reactions in Drug Biotransformation (ed. A. Aitio), Elsevier/Norh Holland Biochemical Press, Amsterdam.
Johnson, G.A., Baker, C.A. and Smith, R.T. (1980). Radioenzymatic assay of sulfate conjugates of catecholamines and dopa in plasma. Life Sci., 26, 1591–1598.
Kraml, M. (1965). A rapid microfluorimetric determination of monoamine oxidase. Biochem. Pharmac., 14, 1683–1685.
Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951). Protein measurement with the Folin phenol reagent. J. biol. Chem., 193, 265–275.
McEntire, J.E., Buchok, S.J. and Papermaster, B.W. (1979). Determination of platelet monoamine oxidase activity in human plateletrich plasma. Biochem. Pharmacol., 28, 2345–2347.
Meek, J.L. and Neff, N.H. (1973). Biogenic amines and their metabolites as substrates for phenol sulphotransferase (EC 2.8.2.1) of brain and liver. J. Neurochem., 21, 1–9.
Metcalfe, D.D., Corash, L.M. and Kaliner, M. (1979). Human platelet arylsulphatases: identification and capacity to destroy SRS-A. Immunology, 37, 723–729.
Murphy, D.L., Costa, J.L., Shafer, B. and Corash, L. (1978). Monoamine oxidase activity in different gradient fractions of human platelets. Psychopharmacology, 59, 193–197.
Pennings, E.J.M., Vrielink, R. and Van Kempen, G.M.J. (1978). Kinetics and mechanism of the rat brain phenol sulphotransferase reaction. Biochem. J., 173, 299–307.
Pennings, E.J.M. and Van Kempen, G.M.J. (1979). Analysis of 3′-phosphoadenylylsulphate and related compounds by pairedion high-performance liquid chromatography. J. Chromatogr., 176, 478–479.
Pennings, E.J.M. and Van Kempen, G.M.J. (1980). Studies on the meta and para 0-sulphation of the catechol compound 3, 4-di-hydroxybenzoic acid by rat liver sulphotransferase in vitro. Biochem. J., 191, 133–138.
Pertoft, H. and Lindahl-Kiessling, K. (1968). Separation of various blood cells in colloidal silica-polyvinylpyrrolidone gradients. Exp. Cell Res., 50, 355–368.
Pharmacia Fine Chemicals (Uppsala, Sweden). Separation News, 1979–1, 1980–3.
Renskers, K.J., Feor, K.D. and Roth, J.A. (1980). Sulfation of dopamine and other biogenic amines by human brain sulfotransferase. J. Neurochem., 34, 1362–1368.
Roy, A.B. and Trudinger, P.A. (1970). The biochemistry of inorganic compounds of sulphur. The University Press, Cambridge.
Sègal, A.W., Fortunato, A. and Herd, T. (1980). A rapid single centrifugation step method for the separation of erythrocytes, granulocytes and mononuclear cells on continuous gradients of Percoll. J. immunol. Methods, 32, 209–214.
Sekura, R.D., Marcus, C.J., Lyon, E.S. and Jakoby, W.B. (1979). Assay of sulfotransferases. Anal. Biochem., 95, 82–86.
Tipton, K.F. (1979). Monoamine oxidase. In The Neurobiology of Dopamine (eds. A.S. Horn, J. Korf and B.H.C. Westerink), Academic Press, New York.
Tyce, G.M., Sharpless, N.S. and Muenter, M.D. (1974). Free and conjugated dopamine in plasma during levodopa therapy. Clin. Pharmacol. Therap., 16, 782–788.
Van Kempen, G.M.J. and Jansen, G.S.I.M. (1972). Quantitative determination of phenolsulfotransferase using 4-methylumbelliferone. Anal. Biochem., 46, 438–442.
Van Kempen, G.M.J., Wolters, W.L. and Van Elk, R. (1975). Distribution of 3-methoxy-4-hydroxyphenylethyleneglycol sulphotransferase in brain fractions. J. Neurochem., 24, 825–827.
Wong, K.P. (1975). The biosynthesis of 3-methoxy-4-hydroxyphenyl-glycol sulphate by liver and brain. J. Neurochem., 24, 1059–1063.
Wong, K.P. and Yeo, T. (1979). Assay of adenosine 3-phosphate 5′-sulphatophosphate in hepatic tissues. Biochem. J., 181, 107–110.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1981 The Contributors
About this chapter
Cite this chapter
Pennings, E.J.M., Van Brussel, J.L., Zanen, J.G., Van Kempen, G.M.J. (1981). Sulfation of MHPG and some other Substrates by Human Platelet Phenolsulfotransferase, PST. In: Sandler, M., Usdin, E. (eds) Phenolsulfotransferase in Mental Health Research. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06118-1_3
Download citation
DOI: https://doi.org/10.1007/978-1-349-06118-1_3
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-06120-4
Online ISBN: 978-1-349-06118-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)