Phenolsulfotransferase Activity and Levels of Catecholamine Sulfates in Rat Brain Tissues
Sulfation constitutes a major pathway in the metabolism of substances containing phenolic hydroxyl groups but its physiological significance and its involvement in human diseases is still unclear. Thus while there was evidence that an increased sulfation of glucocorticoid accompanies elevated blood pressure in several types of experimental hypertension in rats (Singer et al, 1977) other report suggested a lack of sulfoconjugation of tyramine as a contributory factor in tyramine sensitive migraine (Youdim et al, 1971). Earlier Richter and MacIntosh (1941) had demonstrated that conjugation of adrenaline markedly reduced its pressor properties and proposed that conjugation is a mechanism of inactivation of the biological properties of this amine.
KeywordsHuman Platelet Sulfate Ester Bovine Serum Albumine Experimental Hypertension Free Sulfate
Unable to display preview. Download preview PDF.
- Anderson R., Weinshilboum R., Philips S. and Broughton D. (1980). Human Platelet Phenolsulphotransferase (PST) Activity: Correlation with PST Activity in the Kidney and Gut. Pharmacologist 22(3): p. 301.Google Scholar
- Buu N.T., Duhaime J., Savard C., Truong L. and Kuchel O. (1981). Presence of Conjugated Catecholamines in Rat Brain: A New Method of Analysis of Catecholamine Sulfates. J. Neurochem. (in press).Google Scholar
- Kuchel O., Buu N.T., Hamet P., Larochelle P. and Bourque M. (1981). Catecholamine Sulfates and Platelet Phenolsulfotransferase (PST) Activity in Human Hypertension. In Phenolsulfotransferase, Usdin E. & Sandler M. (eds) Macmillan Publishers Ltd. England, in press.Google Scholar
- Richter D. and MacIntosh F.C. (1941). Adrenaline Ester. Am. J. Physiol. 135:1–5.Google Scholar