Phenolsulfotransferase Activity and Levels of Catecholamine Sulfates in Rat Brain Tissues
Sulfation constitutes a major pathway in the metabolism of substances containing phenolic hydroxyl groups but its physiological significance and its involvement in human diseases is still unclear. Thus while there was evidence that an increased sulfation of glucocorticoid accompanies elevated blood pressure in several types of experimental hypertension in rats (Singer et al, 1977) other report suggested a lack of sulfoconjugation of tyramine as a contributory factor in tyramine sensitive migraine (Youdim et al, 1971). Earlier Richter and MacIntosh (1941) had demonstrated that conjugation of adrenaline markedly reduced its pressor properties and proposed that conjugation is a mechanism of inactivation of the biological properties of this amine.
KeywordsPermeability Hydrolysis Phenol Hydroxyl Dopamine
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