Abstract
Much of present day cancer chemotherapy relies heavily on inhibition of nucleic acid synthesis or interference with mitosis as a means of discriminating selectively against fast growing tumour cells (Pratt and Ruddon, 1979; Cassady and Douros, 1980). There is much pharmacological evidence (antimitotic, cytological and mutagenic effects, and the inactivation of viruses) indicating that DNA is the principal cell target for many antitumour agents (Montgomery et al., 1970; Ross, 1962; Gale et al., 1981; Wheeler, 1962). The object of this chapter is to review the structure and chemical characteristics of antitumour drugs, the chemistry and topology of DNA as a drug target, and the nature of specific chemical changes that drugs induce in nucleic acids. For this purpose we may define ‘damage’ to DNA as any alteration involving chemical bond formation or breakage, permanent or transient, which affects the normal cellular function of DNA. The biology of DNA damage is considered in Chapter 10.
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Lown, J.W. (1983). The Chemistry of DNA Damage by Antitumour Drugs. In: Neidle, S., Waring, M.J. (eds) Molecular Aspects of Anti-Cancer Drug Action. Topics in Molecular and Structural Biology. Palgrave, London. https://doi.org/10.1007/978-1-349-06010-8_9
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