Abstract
Since the earliest successes in cancer chemotherapy, which began with the clinical trial of nitrogen mustard (Gilman and Philips, 1946), it was realised that there is something special about compounds having two or more functional groups. As the chemical mechanism of alkylation became clear, it was surmised that the antitumour alkylating agents produce toxic effects due to the formation of covalent crosslinks. By the 1950s, it was suspected that DNA might be the crucial target of crosslinking (Goldacre et al., 1949; Stacey et al., 1958). The model of DNA as a double helix and its role in replication, together with the finding that alkylation can occur on the ring nitrogens of the bases (Brookes and Lawley, 1960, 1961), suggested interstrand crosslinking as a possibly crucial effect, and this phenomenon was soon demonstrated in purified DNA and in cells (Geiduschek, 1961; Iyer and Szybalski, 1963; Kohn et al., 1965, 1966).
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Kohn, K.W. (1983). Biological Aspects of DNA Damage by Crosslinking Agents. In: Neidle, S., Waring, M.J. (eds) Molecular Aspects of Anti-Cancer Drug Action. Topics in Molecular and Structural Biology. Palgrave, London. https://doi.org/10.1007/978-1-349-06010-8_10
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