Abstract
At first glance DNA appears to be a structurally rather unadventurous molecule when compared to the multitude of known RNA structures. This arises from the fact that it is usually found completely hydrogen-bonded to its complementary sequence, except for the single-stranded forms of some DNA viruses. The most impressive aspect of a molecular model of DNA in the B-form Langridge et al., 1960b) is probably the smooth symmetrical nature of the molecule. Yet from a functional point of view it is clear that particular regions of DNA sequence, such as promoters and replication origins, must be in some manner distinct, and some sequence-dependent structural polymorphism would be advantageous.
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Lilley, D.M.J. (1982). Hairpin-loops in supercoiled DNA. In: Neidle, S. (eds) Topics in Nucleic Acid Structure. Topics in Molecular and Structural Biology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06007-8_4
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