Abstract
There is mounting evidence that many opiate-like peptides do not always exhibit some of the classic signs of opiate action possessed by morphine and its alkaloidal agonist surrogates. The explanation offered by most investigators is that a multiplicity of opiate receptors exist with varying degrees of affinity for various opioid agonists. This variation in activity extends not only to different organs and tissues but also to different sites within the brain itself. Furthermore, there is considerable species and strain difference in this regard. This obviously means that many of the effects noted with the opiate-like peptides in experimental animals cannot always be extrapolated for accurate prediction of pharmacological effects in humans.
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Way, E.L. (1980). Relationships of γ-Endorphin in Physical Dependence. In: Turner, P., Padgham, C., Hedges, A. (eds) Clinical Pharmacology & Therapeutics. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05952-2_42
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DOI: https://doi.org/10.1007/978-1-349-05952-2_42
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