Endorphins and Central Neurotransmitters in Clinical Pain
Present-day knowledge about the chemical transmitters involved in pain and pain modulation is immensely more advanced than only a few years ago. This knowledge extends into at least four different areas, the primary afferent system, the circuitry at the level of the first synapse in the dorsal horn of the spinal cord, supraspinal sites of pain modulation and finally the descending control systems. The problem we address ourselves is how this new knowledge can be applied to clinical pain, to generate disease models and to develop new treatment strategies.
KeywordsPlacebo Catheter Depression Dopamine Covariance
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