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Clinical Pharmacology & Therapeutics pp 213–223Cite as

Palgrave Macmillan

The Effect of Platelet Regulatory Drugs in Experimental Models of Thrombosis, Atherosclerosis and Myocardial Ischaemia

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Abstract

Three drugs continue to be under intensive clinical assessment to determine whether they can reduce mortality and morbidity following thrombo-occlusive cerebro-vascular or cardiovascular accidents. These drugs are aspirin, dipyridamole and sulphinpyrazone. The most recent trials to be completed are those relating to sulphinpyrazone (Anturane Reinfarction Trial Research Group, 1980), aspirin (Aspirin Myocardial Infarction Study Research Group, 1980) and aspirin alone or in combination with dipyridamole (Persantine-Aspirin Reinfarction Study Research Group, 1980). None of these drugs were invented for use after stroke or myocardial infarction and much effort has gone into their investigation in animal models thought to have some bearing on the development or the consequences of vessel disease in man. In this review attention will be paid to data derived from in vivo animal models in which either thrombus formation and changes in the intima and media of the vasculature occur as a result of direct injury to the endothelium, or in which platelet aggregation follows from the administration of a known platelet agonist. For the most part discussion of the effect of these drugs on the heart will derive from variants of the well-known coronary ligation models.

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  1. Ciba-Geigy Pharmaceuticals Division, Wimblehurst Road, Horsham, West Sussex, RH12 4 AB, England

    A. M. White & K. D. Butler

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  1. A. M. White
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P. Turner C. Padgham A. Hedges

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White, A.M., Butler, K.D. (1980). The Effect of Platelet Regulatory Drugs in Experimental Models of Thrombosis, Atherosclerosis and Myocardial Ischaemia. In: Turner, P., Padgham, C., Hedges, A. (eds) Clinical Pharmacology & Therapeutics. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05952-2_22

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