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The Mechanisms of Action of Drugs that Modify Platelet and Vessel Wall Function

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Clinical Pharmacology & Therapeutics

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Abstract

Many drugs that modify platelet or vessel wall functions have been recognized and are being investigated for their potential usefulness in modifying thromboembolic events. An understanding of the effects of these drugs involves knowledge of the factors that initiate thrombosis and of the different types of thrombosis.

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References

  • Ali, M. & McDonald, J. W. D. (1978). Reversible and irreversible inhibition of platelet cyclo-oxygenase and serotonin release by non-steroidal anti-inflammatory drugs. Thromb. Res., 13, 1057–1066

    Article  CAS  PubMed  Google Scholar 

  • Andersen, M. P., Bechsgaard, P., Frederiksen, J., Hansen, D. A., Jürgensen, H. J., Nielsen, B., Pedersen, F., Pedersen-Bjergaard, O. & Rasmussen, S. L. (1979). Effect of alprenolol on mortality among patients with definite or suspected acute myocardial infarction. Lancet, 2, 865–867.

    Article  CAS  PubMed  Google Scholar 

  • Anturane Reinfarction Trial Research Group (1978). Sulfinpyrazone in the prevention of cardiac death after myocardial infarction: the Anturane reinfarction trial. New Eng. J. Med., 298, 289–295.

    Article  Google Scholar 

  • Anturane Reinfarction Trial Research Group (1980). Sulfinpyrazone in the prevention of sudden death after myocardial infarction. New Eng. J. Med., 302, 250–256.

    Article  Google Scholar 

  • Ardlie, N. G., Glew, G. & Schwartz, C. J. (1966). Influence of catecholamines on nucleotide-induced platelet aggregation. Nature, 212, 415–417.

    Article  CAS  PubMed  Google Scholar 

  • Aspirin Myocardial Infarction Study Research Group (1980). A randomized controlled trial of aspirin in persons recovered from myocardial infarction. J. Am. med. Ass., 243, 661–669

    Article  Google Scholar 

  • Baenziger, N. L., Force, L. E. & Becherer, P. R. (1980). Histamine stimulates prostacyclin synthesis in cultured human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun., 92, 1435–1440.

    Article  CAS  PubMed  Google Scholar 

  • Baumgartner, H. R., Muggli, R., Tschopp, T. B. & Turitto, V. T. (1976). Platelet adhesion, release and aggregation in flowing blood: effects of surface properties and platelet function. Thromb. Haemost., 35, 124–138.

    CAS  PubMed  Google Scholar 

  • Baumgartner, H. R. & Studer, A. (1977). Platelet factors and the proliferation of vascular smooth muscle cells. In Atherosclerosis IV ed. Schettler, G., Goto, Y., Hata Y. & Klose, G. pp. 605–609. Berlin: Springer Verlag.

    Chapter  Google Scholar 

  • Bell, R. L., Kennerly, D. A., Stanford, N. & Majerus, P. W. (1979). Diglyceride lipase: A pathway for arachidonate release from human platelets. Proc. Nat. Acad. Sci. USA, 76, 3238–3241.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Best, L. C., McGuire, M. B., Jones, P. B. B., Holland, T. K., Martin, T. J., Preston, F. E., Segal, D. S. & Russell, R. G. G. (1979). Mode of action of dipyridamole on human platelets. Thromb. Res., 16, 367–379.

    Article  CAS  PubMed  Google Scholar 

  • Blackwell, G. J. (1978). Phospholipase A2 and platelet aggregation. In Advances in Prostaglandin and Thromboxane Research Vol. 3, ed. Galli, C., Galli, G. & Porcellati G. pp. 137–142. New York: Raven Press.

    Google Scholar 

  • Blumberg, A. L., Denny, S. E., Marshall, G. R. & Needleman, P. (1977). Blood vessel-hormone interactions: angiotensin, bradykinin and prostaglandins. Am. J. Physiol., 232, H305–H310.

    Google Scholar 

  • Boston Collaborative Drug Surveillance Group (1974). Regular aspirin intake and acute myocardial infarction. Brit. med. J., 1, 440–443.

    Article  Google Scholar 

  • Breddin, K., Loew, D., Lechner, K., Ãœberla, K. & Walter, E. (1979). Secondary prevention of myocardial infarction. Comparison of acetylsalicylic acid, phenprocoumon and placebo. A multicenter two-year prospective study. Thromb. Haemost., 40, 225–236.

    Google Scholar 

  • Buchanan, M. R., Dejana, E., Mustard, J. F. & Hirsh, J. (1979). Prolonged inhibition of PGI2 production and associated increased thrombogenic effect in arteries after aspirin administration. Thromb. Haemost., 42, 61.

    Google Scholar 

  • Buchanan, M. R., Rosenfeld, J. & Hirsh, J. (1978). The prolonged effect of sulfinpyrazone on collagen-induced platelet aggregation in vivo. Thromb. Res., 13, 883–892.

    Article  CAS  PubMed  Google Scholar 

  • Burch, J. W., Baenziger, N. L., Stanford, N. & Majerus, P. W. (1978a). Sensitivity of fatty acid cyclo-oxygenase from human aorta to acetylation by aspirin. Proc. Nat. Acad. Sci. USA, 75, 5181–5184.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Burch, J. W., Stanford, N. & Majerus, P. W. (1978b). Inhibition of platelet prostaglandin synthetase by oral aspirin. J. clin. Invest., 61, 314–319.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Butler, A. M., Gerrard, J. M., Peller, J., Stoddard, S. F., Rao, G. H. R. & White, J. G. (1979). Vitamin E inhibits the release of calcium from a platelet membrane fraction in vitro. Prostag. Med., 2, 203–216.

    Article  CAS  Google Scholar 

  • Butler, K. D., Dieterle, W., Maguire, E. D., Pay, G. F., Wallis, R. B. & White, A. M. (1980). Sustained effects of sulfinpyrazone. In Cardiovascular Actions of Sulfinpyrazone: Basic and Clinical Research ed. McGregor, M., Mustard, J. F., Oliver, M. F. & Sherry, S. pp. 19–35. Miami, Florida: Symposia Specialists.

    Google Scholar 

  • Carvalho, A. C. A., Colman, R. W. & Lees, R. S. (1974). Clofibrate reversal of platelet hypersensitivity in hyperbetalipoproteinemia. Circulation, 50, 570–574.

    Article  CAS  PubMed  Google Scholar 

  • Cazenave, J. -P., Davies, J. A., Senyi, A. F., Blajchman, M. A., Hirsh, J. & Mustard, J. F. (1976). Effects of methylprednisolone on platelet adhesion to damaged aorta, bleeding time and platelet survival. Blood, 48, 1009.

    Google Scholar 

  • Cazenave, J. -P., Dejana, E., Kinlough-Rathbone, R. L., Richardson, M., Packham, M. A. & Mustard, J. F. (1979). Prostaglandins I2 and E1 reduce rabbit and human platelet adherence without inhibiting serotonin release from adherent platelets. Thromb. Res., 15, 273–279.

    Article  CAS  PubMed  Google Scholar 

  • Cazenave, J. -P., Kinlough-Rathbone, R. L., Packham, M. A. & Mustard, J. F. (1978a). The effect of acetylsalicylic acid and indomethacin on rabbit platelet adherence to collagen and the subendothelium in the presence of a low or high hematocrit. Thromb. Res., 13, 971–981.

    Article  CAS  PubMed  Google Scholar 

  • Cazenave, J. -P., Packham, M. A., Davies, J. A., Kinlough-Rathbone, R. L. & Mustard, J. F. (1978b). Studies of platelet adherence to collagen and the subendothelium. In Platelet Function Testing, ed. Day, H. J., Holmsen, H. & Zucker, M. B. pp. 181–198. DHEW Publication No. (NIH) 78–1087 U. S. Government Printing Office: Washington, D. C.

    Google Scholar 

  • Chalmers, T. C., Matta, R. J., Smith, J., Jr. & Kunzler, A. M. (1977). Evidence favoring the use of anticoagulants in the hospital phase of acute myocardial infarction. New Eng. J. Med., 297, 1091–1096.

    Article  CAS  PubMed  Google Scholar 

  • Clopath, P., Horsch, A. K. & Dieterle, W. (1980). Effect of sulfipyrazone on development of atherosclerosis in various animal models. In Cardiovascular Actions of Sulfinpyrazone: Basic and Clinical Research ed. McGregor, M., Mustard, J. F., Oliver, M. F. & Sherry, S. pp. 121–137. Miami, Florida: Symposia Specialists.

    Google Scholar 

  • Clowes, A. W. & Karnovsky, M. J. (1977). Failure of certain antiplatelet drugs to affect myointimal thickening following arterial endothelial injury in the rat. Lab. Invest., 36, 452–464.

    CAS  PubMed  Google Scholar 

  • Colman, R. W. (1978). Platelet function in hyperbetalipoproteinemia. Thromb. Haemost., 39, 284–293.

    CAS  PubMed  Google Scholar 

  • Colman, R. W., Bennett, J. S., Sheridan, J. F., Cooper, R. A. & Shattil, S. J. (1976). Halofenate: A potent inhibitor of normal and hypersensitive platelets. J. lab. clin. Med., 88, 282–291.

    CAS  PubMed  Google Scholar 

  • Coronary Drug Project Research Group (1976). Aspirin in coronary heart disease. J. chronic Dis., 29, 625–642.

    Article  Google Scholar 

  • Czervionke, R. L., Smith, J. B., Fry, G. L., Hoak, J. C. & Haycraft, D. L. (1979). Inhibition of prostacyclin by treatment of endothelium with aspirin. Correlation with platelet adherence. J. clin. Invest, 63, 1089–1092.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • David, J. -L., Monfort, F., Herion, F. & Raskinet, R. (1979). Compared effects of three dose-levels of ticlopidine on platelet function in normal subjects. Thromb. Res., 14, 35–49.

    Article  CAS  PubMed  Google Scholar 

  • Davis, R. F. & Engleman, E. G. (1974). Incidence of myocardial infarction in patients with rheumatoid arthritis. Arth. Rheumat., 17, 527–533.

    Article  CAS  Google Scholar 

  • De Gaetano, G., Miragliotta, G., Roncucci, R., Lansen, J. & Lambelin, G. (1976). Suloctidil: A novel inhibitor of platelet aggregation in human beings. Thromb. Res., 8, 361–371.

    Article  PubMed  Google Scholar 

  • Dejana, E., Cazenave, J. -P., Groves, H. M, Kinlough-Rathbone, R. L., Richardson, M., Packham, M. A. & Mustard, J. F. (1980). The effect of aspirin inhibition of PGI2 production on platelet adherence to normal and damaged rabbit aortae. Thromb. Res., 17, 453–464.

    Article  CAS  PubMed  Google Scholar 

  • Didisheim, P. (1972). Animal models useful in the study of thrombosis and antithrombotic agents. In Progress in Hemostasis and Thrombosis. Vol. 1, ed. Spaet, T. H. pp. 165–197. New York: Grune and Stratton.

    Google Scholar 

  • Di Minno, G., de Gaetano, G. & Garattini, S. (1978). Dipyridamole and platelet function. Lancet, 2, 1258–1259.

    CAS  Google Scholar 

  • Ehrman, M., Jaffe, E. A. & Weksler, B. B. (1979). Prostacyclin (PGI2) inhibits the development in platelets of ADP and arachidonate-mediated shape change and procoagulant activity. Clin. Res., 27, 293A.

    Google Scholar 

  • Eldor, A. & Weksler, B. B. (1979). Heparin and dextran sulfate antagonize PGI2 inhibition of platelet aggregation. Thromb. Res., 16, 617–628.

    Article  CAS  PubMed  Google Scholar 

  • Elwood, P. C., Cochrane, A. L., Burr, M. L., Sweetnam, P. M., Williams, G., Welsby, E., Hughes, S. J. & Renton, R. (1974). A randomized controlled trial of acetylsalicylic acid in the secondary prevention of mortality from myocardial infarction. Brit. med. J., 1, 436–440.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Elwood, P. C. & Sweetnam, P. M. (1979). Aspirin and secondary mortality after myocardial infarction. Lancet, 2, 1313–1315.

    Article  CAS  PubMed  Google Scholar 

  • Favis, G. R. & Colman, R. W. (1978). The action of halofenate on platelet shape change and prostaglandin synthesis. J. lab. clin. Med., 92, 45–52.

    CAS  PubMed  Google Scholar 

  • Fields, W. S., Lemak, N. A., Frankowski, R. F. & Hardy, R. J. (1977). Controlled trial of aspirin in cerebral ischemia. Stroke, 8, 301–316.

    Article  CAS  PubMed  Google Scholar 

  • Flower, R. (1978). Steroidal anti-inflammatory drugs as inhibitors of phospholipase A2. In Advances in Prostaglandin and Thromboxane Research Vol 3, ed. Galli, C., Galli, G. & Porcellati, G. pp. 105–112. New York: Raven Press.

    Google Scholar 

  • Flower, R. J. & Blackwell, G. J. (1976). The importance of phospholipase A2 in prostaglandin biosynthesis. Biochem. Pharmac., 25, 285–291.

    Article  CAS  Google Scholar 

  • Fong, J. S. C. (1976). α-tocopherol: its inhibition on human platelet aggregation. Experientia, 32, 639–641.

    Article  CAS  PubMed  Google Scholar 

  • Frishman, W. H., Weksler, B., Christodoulou, J. P., Smithen, C. & Killip, T. (1974). Reversal of abnormal platelet aggregability and changes in exercise tolerance in patients with angina pectoris following oral propranolol. Circulation, 50, 887–896.

    Article  CAS  PubMed  Google Scholar 

  • Frohlich, E. D. (1980). Are beta blockers too dangerous for general clinical use? In Controversies in Therapeutics ed. Lasagna, L. pp. 350–357. Philadelphia: W. B. Saunders.

    Google Scholar 

  • Genton, E. & Steele, P. (1977). Platelet survival time-alteration with disease and drug treatment. In Thromboembolism, A New Approach to Therapy ed. Mitchell, J. R. A. & Domenet, J. G. pp. 104–122. New York: Academic Press.

    Google Scholar 

  • Gilbert, J. B. & Mustard, J. F. (1963). Some effects of Atromid on platelet economy and blood coagulation in man. J. Atheroscl. Res., 3, 623–633.

    Article  CAS  Google Scholar 

  • Glynn, M. F., Murphy, E. A. & Mustard, J. F. (1967). Effect of Clofibrate on platelet economy in man. Lancet, 2, 447–448.

    Article  CAS  PubMed  Google Scholar 

  • Gordon, J. L. & Pearson, J. D. (1978). Effects of sulfinpyrazone and aspirin on prostacyclin synthesis by endothelial cells. Brit. J. Pharmac., 64, 481–484.

    Article  CAS  Google Scholar 

  • Groman, R. R. (1979). Modulation of human platelet function by prostacyclin and thromboxane A2. Fed. Proc, 38, 83–88

    Google Scholar 

  • Greenwald, J. E., Wong, L. K., Rao, M., Bianchine, J. R. & Panganamala, R. V. (1978). A study of three vasodilating agents as selective inhibitors of thromboxane A2 biosynthesis. Biochem. Biophys. Res. Commun. 84, 1112–1118.

    Article  CAS  PubMed  Google Scholar 

  • Groves, H. M., Kinlough-Rathbone, R. L., Richardson, M., Moore, S. & Mustard, J. F. (1979). Platelet interaction with damaged rabbit aorta. Lab. Invest., 40, 194–200.

    CAS  PubMed  Google Scholar 

  • Gunning, A. J. Pickering, G. W., Robb-Smith, A. H. T. & Russell, R. R. (1964). Mural thrombosis of the internal carotid artery and subsequent embolism. Quart. J. Med., 33, 155–195.

    CAS  PubMed  Google Scholar 

  • Gurwich, V. & Lipinski, B. (1976). Evaluation of anti-thrombotic properties of suloctidil in comparison with aspirin and dipyridamole. Thromb. Res., 9, 101–108

    Article  Google Scholar 

  • Haft, J. I. & Fani, K. (1973). Stress and the induction of intravascular platelet aggregation in the heart. Circulation, 48, 164–169.

    Article  CAS  PubMed  Google Scholar 

  • Harker, L. A. (1980). Sulfinpyrazone in primate models of vascular disease. In Cardiovascular Actions of Sulfinpyrazone: Basic and Clinical Resarch ed. McGregor, M., Mustard, J. F., Oliver, M. F. & Sherry, S. pp. 81–98. Miami, Florida: Symposia Specialists.

    Google Scholar 

  • Harker, L. A. & Slichter, S. J. (1972). Platelet and fibrinogen consumption in man. New Eng. J. Med., 287, 999–1005.

    Article  CAS  PubMed  Google Scholar 

  • Haslam, R. J. (1973). Interactions of the pharmacological receptors of blood platelets with adenylate cyclase. Ser. Haemal VI, 3, 333–350.

    Google Scholar 

  • Haslam, R. J., Davidson, M. M. L., Davies, T., Lynham, J. A. & McClenaghan, M. D. (1978). Regulation of blood platelet function by cyclic nucleotides. Adv. cyclic Nucl. Res., 9, 533–552.

    CAS  Google Scholar 

  • Hawiger, J. & White, R. B. (1978). Propranolol and prostacyclin inhibit human platelet phospholipase A2-induced release of arachidonic acid. Circulation, 58, 11–137.

    Google Scholar 

  • Higgs, E. A., Moncada, S., Vane, J. R., Caen, J. P., Michel, H. & Tobelem, G. (1978). Effect of prostacyclin (PGI2) on platelet adhesion to rabbit arterial subendothelium. Prostaglandins, 16, 17–22.

    Article  CAS  PubMed  Google Scholar 

  • Hokama, Y., Morita, A. H., Abad, M. A., Joyo, B. S., Uchida, D. A. & Fischer, G. W. (1978). Effect of levamisole on aggregation of platelets stimulated with compounds associated with the prostaglandin synthetic pathway. Res. Commun. chem. Path. Pharmac. 19, 141–149.

    CAS  Google Scholar 

  • Hong, S.-C. L. & Levine, L. (1976). Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids. Proc. Nat. Acad. Sci. USA, 73, 1730–1734.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Horrobin, D. F., Ally, A. L, Manku, M. S. (1978). Dipyridamole and platelet aggregation. Lancet, 2, 270.

    Article  Google Scholar 

  • Hovig, T. (1963). Release of platelet-aggregating substance (adenosine diphosphate) from rabbit blood platelets induced by saline ‘extract’ of tendons. Thromb. Diath. Haemorrh., 9, 264–278.

    CAS  Google Scholar 

  • Jaffe, E. A. & Weksler, B. B. (1979). Recovery of endothelial cell prostacyclin production after inhibition by low doses of aspirin. J. clin. Invest, 63, 532–535.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Jesse, R. L. & Franson, R. C. (1979). Modulation of purified phospholipase A2 activity from human platelets by calcium and indomethacin. Biochim. Biophys. Acta, 575, 467–470.

    Article  CAS  PubMed  Google Scholar 

  • Johnson, M. & Heywood, J. B. (1979). Possible mode of action of ticlopidine: a novel inhibitor of platelet aggregation. Thromb. Haemost., 42, 367.

    CAS  Google Scholar 

  • Jørgensen, L., Packham, M. A., Rowsell, H. C. & Mustard, J. F. (1972). Deposition of formed elements of blood on the intima and signs of intimai injury in the aorta of rabbit, pig and man. Lab. Invest., 27, 341–350.

    PubMed  Google Scholar 

  • Kelton, J. G., Hirsh, J., Carter, C. J. & Buchanan, M. R. (1978). Thrombogenic effect of high-dose aspirin in rabbits. Relationship to inhibition of vessel wall synthesis of prostaglandin I2-like activity. J. clin. Invest., 62, 892–895.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Kinlough-Rathbone, R. L., Cazenave, J.-P., Packham, M. A. & Mustard, J. F. (1980a). Effect of inhibitors of the arachidonate pathway on the release of granule contents from rabbit platelets adherent to collagen. Lab. Invest., 42, 28–34.

    CAS  PubMed  Google Scholar 

  • Kinlough-Rathbone, R. L., Groves, H. M., Cazenave, J.-P., Richardson, M. & Mustard, J. F. (1978). Effect of dipyridamole and aspirin on platelet adherence to damaged rabbit aortas in vitro and in vivo. Fed. Proc, 37, 260.

    Google Scholar 

  • Kinlough-Rathbone, R. L., Groves, H. M., Jørgensen, L., Richardson, M., Moore, S., Packham, M. A. & Mustard, J. F. (1980b). The role of thrombin in the response of platelets to injury of the rabbit aorta. Clin. Res., 28, 548A.

    Google Scholar 

  • Kinlough-Rathbone, R. L., Packham, M. A. & Mustard, J. F. (1970). The effect of prostaglandin E1 on platelet function in vitro and in vivo. Brit. J. Haematol., 19, 559–571.

    Article  CAS  Google Scholar 

  • Knudsen, J. B. & Gormsen, J. (1979). The effect of ticlopidine on platelet function in normal volunteers and in patients with platelet hyperaggregability in vitro. Thromb. Res., 16, 663–671.

    Article  CAS  PubMed  Google Scholar 

  • Kurokawa, I., Kimura, T., Nagai, T. & Mitsuo, K. (1971). The effect of vitamin E on the adenosine diphosphate induced platelet aggregation. J. Vitamin, 17, 181–184.

    Article  CAS  PubMed  Google Scholar 

  • Levin, R. I., Weksler, B. B. & Jaffe, E. A. (1980). Nitroglycerin induces production of prostacyclin by human endothelial cells. Circulation Res., 28, 471A.

    Google Scholar 

  • Lin, C. Y. & Smith, S. (1976). The effect of halofenate and Clofibrate on aggregation and release of serotonin by human platelets. Life Sci., 18, 563–568.

    Article  CAS  PubMed  Google Scholar 

  • Linos, A., Worthington, J. W., O’Fallon, W., Fuster, V., Whisnant, J. P. & Kurland, L. T. (1978). Effect of aspirin on prevention of coronary and cerebrovascular disease in patients with rheumatoid arthritis. A long-term follow-up study. Mayo Clin. Proc., 53, 581–586.

    CAS  PubMed  Google Scholar 

  • Majno, G. & Joris, I. (1978). Endothelium 1977: A review. In The Thrombotic Process in Atherogenesis ed. Chandler, A. B., Eurenius, K., McMillan, G. C., Nelson, C. B., Schwartz C. J. & Wessler, S. Adv. exp. Med. Biol., 104, 169–225.

    Chapter  Google Scholar 

  • Maling, H. M. & Highman, B. (1958). Exaggerated ventricular arrhythmias and myocardial fatty changes after large doses of norepinephrine and epinephrine in unanesthetized dogs. Am. J. Physiol., 194, 590–596.

    CAS  PubMed  Google Scholar 

  • Marcus, A. J. (1978). The role of lipids in platelet function: with particular reference to the arachidonic acid pathway. J. Lipid Res., 19, 793–826.

    CAS  PubMed  Google Scholar 

  • Masotti, G., Galanti, G., Poggesi, L., Abbate, R. & Neri Serneri, G. G. (1979). Differential inhibition of prostacyclin production and platelet aggregation by aspirin. Lancet, 2, 1213–1216.

    Article  CAS  PubMed  Google Scholar 

  • McKenna, R., Galante, J., Bachmann, F., Wallace, D. L., Kaushal, S. P. & Meredith, P. (1980). Prevention of venous thromboembolism after total knee replacement by high-dose aspirin or intermittent calf and thigh compression. Brit. med. J., 1, 514–517.

    Article  Google Scholar 

  • Mehta, J. & Mehta, P. (1979). Platelet function studies in heart disease. VI. Enhanced platelet aggregate formation activity in congestive heart failure: inhibition by sodium nitro-prusside. Circulation, 60, 497–503.

    Article  CAS  PubMed  Google Scholar 

  • Mills, D. C. B. & Macfarlane, D. E. (1976). Suloctidil: A potential antithrombotic agent. Effects on human platelets in vitro. Fed. Proc., 35, 807.

    Google Scholar 

  • Mills, D. C. B. & Roberts, G. C. K. (1967). Effects of adrenaline on human blood platelets. J. Physiol., 193, 443–453.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Mitchell, J. R. A. & Sharp, A. A. (1964). Platelet clumping in vitro. Brit. J. Haematol., 10, 78–93.

    Article  CAS  Google Scholar 

  • Modan, B., Shani M., Schor, S. & Modan, M. (1975). Reduction of hospital mortality from acute myocardial infarction by anticoagulant therapy. New Eng. J. Med., 292, 1359–1362.

    Article  CAS  PubMed  Google Scholar 

  • Moncada, S., Bunting, S., Mullane, K., Thorogood, P., Vane, J. R., Raz, A. & Needleman, P. (1977). Imidazole — selective inhibitor of thromboxane synthetase. Prostaglandins, 13, 611–618.

    Article  CAS  PubMed  Google Scholar 

  • Moncada, S. & Vane, J. R. (1978). Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. Pharmac. Rev., 30, 293–331.

    CAS  Google Scholar 

  • Moore, S. & Mersereau, W. A. (1968). Microembolic renal ischemia, hypertension, and nephrosclerosis. Arch. Pathol., 85, 623–630.

    CAS  PubMed  Google Scholar 

  • Moschos, C. B., Haider, B., De La Cruz, C. Jr., Lyons, M. M. & Regan, T. J. (1978). Antiarrhythmic effects of aspirin during nonthrombotic coronary occlusion. Circulation, 57, 681–684.

    Article  CAS  PubMed  Google Scholar 

  • Mustard, J. F. & Packham, M. A. (1978). Platelets, thrombosis and drugs. In Cardiovascular Drugs: Antithrombotic Drugs Vol. 3, ed. Avery, G. S. pp. 1–83. New York: Adis Press.

    Google Scholar 

  • Mustard, J. F. & Packham, M. A. (1979). The reaction of the blood to injury. In Inflammation, Immunity and Hypersensitivity. 2nd edition, ed. Movat, H. Z. pp. 557–664. New York: Harper & Row.

    Google Scholar 

  • Nahas, G. G., Brunson, J. G., King, W. M. & Cavert, H. M. (1958). Functional and morphologic changes in heart lung preparations following administration of adrenal hormones. Am. J. Pathol, 34, 717–729.

    PubMed Central  CAS  PubMed  Google Scholar 

  • Needleman, P., Kulkarni, P. S. & Raz, A. (1977). Coronary tone modulation: formation and actions of prostaglandins, endoperoxides, and thromboxanes. Science, 195, 409–412.

    Article  CAS  PubMed  Google Scholar 

  • Nickerson, M. & Collier, B. (1975). Drugs inhibiting adrenergic nerves and structures innervated by them. In The Pharmacological Basis of Therapeutics 5th edition, ed. Goodman, L. S. & Gilman, A. pp. 533–564. New York: MacMillan Publishing Co.

    Google Scholar 

  • Niewiarowski, S., Likasiewicz, H., Nath, N & Sha, A. T. (1975). Inhibition of human platelet aggregation by dipyridamole and two related compounds and its modification by acid glycoproteins of human plasma. J. lab. clin. Med., 86, 64–76.

    CAS  PubMed  Google Scholar 

  • Norris, R. M., Clarke, E. D., Sammel, N. L., Smith, W. M. & Williams, B. (1978). Protective effect of propranolol in threatened myocardial infarction. Lancet, 2, 907–909.

    Article  CAS  PubMed  Google Scholar 

  • O’Brien, J. R., Etherington, M. D. & Shuttleworth, R. D. (1978). Ticlopidine — an antiplatelet drug: effects in human volunteers. Thromb. Res., 13, 245–254.

    Article  PubMed  Google Scholar 

  • Özge, A. H. & Mustard, J. F. (1964). The effect of repeated adrenaline injection on blood coagulation and platelet economy in rabbits. Proc. IXth Congress Int. Soc. Hematol., 2, 35–41.

    Google Scholar 

  • Özge, A. H., Rowsell, H. C., Downie, H. G. & Mustard, J. F. (1966). The effect of adrenaline infusions on blood coagulation in normal and haemophilia B dogs. Thromb. Diath. Haemorrh., 15, 349–364.

    PubMed  Google Scholar 

  • Packham, M. A., Kinlough-Rathbone, R. L., Reimers, H.-J., Scott, S. & Mustard, J. F. (1977). Mechanisms of platelet aggregation independent of adenosine diphosphate. In Prostaglandins in Hematology ed. Silver, M. J., Smith, J. B & Kocsis, J. J. pp. 247–276. New York: Spectrum Publications.

    Google Scholar 

  • Packham, M. A. & Mustard, J. F. (1977). Clinical pharmacology of platelets. Critical review. Blood, 50, 555–573.

    CAS  PubMed  Google Scholar 

  • Packham, M. A. & Mustard, J. F. (1980). Pharmacology of platelet-affecting drugs. Circulation, in press.

    Google Scholar 

  • Pfister, B. & Imhof, P. (1979). Influence of vasodilators used in the therapy of heart failure on platelet aggregation. Agents & Actions, 9, 217–219.

    Article  CAS  Google Scholar 

  • Philp, R. B. (1979). Experimental animal models of arterial thrombosis and the screening of platelet-inhibiting, anti-thrombotic drugs: a review. Meth. Find. exp. clin. Pharmac., 1, 197–224.

    CAS  Google Scholar 

  • Pierce, C. H., Oshiro, G. & Nickerson, M. (1974). Effects of methylprednisolone sodium succinate (MP) on platelet aggregation. Circulation, 49 & 50, Supp. 3, III–289.

    Google Scholar 

  • Reches, A., Eldor, A. & Salomon, Y. (1979). Heparin inhibits PGEi-sensitive adenylate cyclase and antagonizes PGE1 antiaggregating effect in human platelets. J. lab. clin. Med, 93, 638–644.

    CAS  PubMed  Google Scholar 

  • Reece, A. H. & Walton, P. L. (1979). Inhibition of intimai proliferation of rabbit aorta by ticlopidine. Thromb. Haemost., 42, 367.

    Google Scholar 

  • Report of the Working Party on Anticoagulant Therapy in Coronary Thrombosis to the Medical Research Council (1969). Assessment of short-term anticoagulant administration after cardiac infarction. Brit. med. J., 1, 335–342.

    Article  Google Scholar 

  • Rittenhouse-Simmons, S. (1979). Production of diglyceride from phosphatidylinositol in activated human platelets. J. clin. Invest., 63, 580–587.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Roba, J., Claeys, M. & Lambelin, G. (1976). Antiplatelet and antithrombotic effects of suloctidil. Eur. J. Pharmac., 37, 265–274.

    Article  CAS  Google Scholar 

  • Roberts, A. J., Jacobstein, J. G., Cipriano, P. R., Alonso, D. R., Combes, J. R. & Gay, W. A., Jr. (1980). Effectiveness of dipyridamole in reducing the size of experimental myocardial infarction. Circulation, 61, 228–236.

    Article  CAS  PubMed  Google Scholar 

  • Robinson, R. W. & LeBeau, R. J. (1967). Platelet adhesiveness and aggregation with chlorophenoxyisobutyric ester. Am. J. med. Sci., 253, 106–112.

    Article  CAS  Google Scholar 

  • Rosenberg, R. D. (1978). Heparin, antithrombin, and abnormal clotting. Ann. Rev. Med., 29, 367–378.

    Article  CAS  PubMed  Google Scholar 

  • Ross, R. & Vogel, A. (1978). The platelet-derived growth factor. Cell, 14, 203–210.

    Article  CAS  PubMed  Google Scholar 

  • Roth, G. J. & Majerus, P. W. (1977). Acetylation of prostaglandin synthetase by aspirin. In Prostaglandins in Hematology ed. Silver, M. J., Smith, J. B. & Kocsis, J. J. pp. 345–360. New York: Spectrum Publications Inc.

    Google Scholar 

  • Rowsell, H. C., Hegardt, B., Downie, H. G., Mustard, J. F. & Murphy, E. A. (1966). Adrenaline and experimental thrombosis. Brit. J. Haematol., 12, 66–73.

    Article  CAS  Google Scholar 

  • Saba, H. I., Saba, S. R., Blackburn, C. A., Hartmann, R. C. & Mason, R. G. (1979). Heparin neutralization of PGI2: effects upon platelets. Science, 205, 499–501.

    Article  CAS  PubMed  Google Scholar 

  • Salzman, E. W., Rosenberg, R. D., Smith, M. H., Lindon, J. N. & Favreau, L. (1980). Effect of heparin and heparin fractions on platelet aggregation. J. clin. Invest., 65, 64–73.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Schrör, K., Moncada, S. & Vane, J. R. (1977). Bradykinin — a powerful prostacyclin (PGX) releasing agent in the heart. Joint Meeting of German and Italian Pharmacologists, Venezia, October 4–6, Book of Abstracts, p. 360.

    Google Scholar 

  • Sinzinger, H., Clopath, P. & Silberbauer, K. (1979). Clofibrate diminishes human vascular prostacyclin synthesis. Artery, 6, 265–266.

    CAS  Google Scholar 

  • Smith, J. B., Ingerman, C., Kocsis, J. J. & Silver, M. J. (1974). Formation of an intermediate in prostaglandin biosynthesis and its association with the platelet release reaction. J. clin. Invest., 53, 1468–1472.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Smith, J. B., Silver, M. J., Ingerman, C. M. & Kocsis, J. J. (1974). Prostaglandin D2 inhibits the aggregation of human platelets. Thromb. Res., 5, 291–299.

    Article  CAS  PubMed  Google Scholar 

  • Smythe, H. A., Ogryzlo, M. A., Murphy, E. A. & Mustard, J. F. (1965). The effect of sulfinpyrazone (anturan) on platelet economy and blood coagulation in man. Can. med. Ass. J., 92, 818–821.

    PubMed Central  CAS  PubMed  Google Scholar 

  • Steele, P., Battock, D. & Genton, E. (1975). Effects of Clofibrate and sulfinpyrazone on platelet survival time in coronary artery disease. Circulation, 52, 473–476.

    Article  CAS  PubMed  Google Scholar 

  • Steiner, M. & Anastasi, J. (1976). Vitamin E. An inhibitor of the platelet release reaction. J. clin. Invest., 57, 732–737.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Stelzer, M. R., Burns, T. S. & Saunders, R. N. (1979). In vivo effect of suloctidil as an antiplatelet agent. Thromb. Haemost., 41, 465–474.

    CAS  PubMed  Google Scholar 

  • Stemerman, M. B. (1973). Thrombogenesis of the rabbit arterial plaque. An electron microscope study. Am. J. Pathol, 73, 7–26.

    PubMed Central  CAS  PubMed  Google Scholar 

  • Svensson, J. & Fredholm, B. B. (1977). Vasoconstrictor effect of thromboxane A2. Acta physiol. Scand., 101, 366–368.

    Article  CAS  PubMed  Google Scholar 

  • Szklo, M, Tonascia, J. A., Goldberg, R. & Kennedy, H. L. (1979). Additional data favouring use of anticoagulant therapy in myocardial infarction. A population-based study. J. Am. med. Ass., 242, 1261–1264.

    Article  CAS  Google Scholar 

  • Tai, H.-H. & Yuan, B. (1978). On the inhibitory potency of imidazole and its derivatives on thromboxane synthetase. Biochem. Biophys. Res. Commun., 80, 236–242.

    Article  CAS  PubMed  Google Scholar 

  • The Canadian Cooperative Study Group (1978). A randomized trial of aspirin and sulfinpyrazone in threatened stroke. New Eng. J. Med., 299, 53–59.

    Article  Google Scholar 

  • Tonascia, J., Gordis, L. & Schmerler, H. (1975). Retrospective evidence favoring use of anticoagulants for myocardial infarction. New Eng. J. Med., 292, 1362–1366.

    Article  CAS  PubMed  Google Scholar 

  • Tschopp, T. B. (1977). Aspirin inhibits platelet aggregation on but not adhesion to, collagen fibrils: an assesment of platelet adhesion and deposited platelet mass by morphometry and 51Cr-labelling. Thromb. Res., 11, 619–632.

    Article  CAS  PubMed  Google Scholar 

  • Vanderhoek, J. Y. & Feinstein, M. B. (1979). Local anesthetics, chlorpromazine and propranolol inhibit stimulus-activation of phospholipase A2 in human platelets. Mol. Pharmac., 16, 171–180.

    CAS  Google Scholar 

  • Villa, S., Livio, M. & de Gaetano, G. (1979). The inhibitory effect of aspirin on platelet and vascular prostaglandins cannot be completley dissociated. Brit. J. Haematol., 42, 425–431.

    Article  CAS  Google Scholar 

  • Vlachakis, N. D. & Aledort, L. (1980). Hypertension and propranolol therapy: Effect on blood pressure, plasma catecholamines and platelet aggregation. Am. J. Cardiol., 45, 321–325.

    Article  CAS  PubMed  Google Scholar 

  • Wasserman, A. J., Gutterman, L. A., Yoe, K. B., Kemp, V. E. Jr. & Richardson, D. W. (1966). Anticoagulants in acute myocardial infarction: the failure of anticoagulants to alter mortality in a randomized series. Am. Heart J., 71, 43–49.

    Article  CAS  PubMed  Google Scholar 

  • Weiss, H. J., Tschopp, T. B. & Baumgartner, H. R. (1975). Impaired interaction (adhesion-aggregation) of platelets with the subendothelium in storage-pool disease and after aspirin ingestion. A comparison with von Willebrand’s disease. New Eng. J. Med., 293, 619–623.

    Article  CAS  PubMed  Google Scholar 

  • Weiss, H. J. & Turitto, V. T. (1979). Prostacyclin (prostaglandin I2, PGI2) inhibits platelet adhesion and thrombus formation on subendothelium. Blood, 53, 244–250.

    CAS  PubMed  Google Scholar 

  • Weksler, B. B., Gillick, M. & Pink, J. (1977a). Effect of propranolol on platelet function. Blood, 49, 185–196.

    CAS  PubMed  Google Scholar 

  • Weksler, B. B., Ley, C. W. & Jaffe, E. A. (1978). Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A 23187. J. clin. Invest., 62, 923–930.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Weksler, B. B., Marcus, A. J. & Jaffe, E. A. (1977b). Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells. Proc. Nat. Acad. Sci. USA, 74, 3922–3926.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Wessler, S. & Gitel, S. N. (1979). Heparin: New concepts relevant to clinical use. Blood, 53, 525–544.

    CAS  PubMed  Google Scholar 

  • Wilkinson, A. R., Hawker, R. J. & Hawker, L. M. (1979). The influence of antiplatelet drugs on platelet survival after aortic damage or implantation of a dacron arterial prosthesis. Thromb. Res., 15, 181–189.

    Article  CAS  PubMed  Google Scholar 

  • Winocour, P. D., Kinlough-Rathbone, R. L. & Mustard, J. F. (1979). Effect of the phospholipase A2 inhibitor mepacrine on aggregation of washed rabbit platelets. Fed. Proc., 38, 1271.

    Google Scholar 

  • Zucker, M. B. (1975). Effect of heparin on platelet function. Thromb. Diath. Haemorrh., 33, 63–65.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, M5S 1A8

    M. A. Packham

  2. Department of Pathology, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5

    J. F. Mustard

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  1. M. A. Packham
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  2. J. F. Mustard
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P. Turner C. Padgham A. Hedges

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Packham, M.A., Mustard, J.F. (1980). The Mechanisms of Action of Drugs that Modify Platelet and Vessel Wall Function. In: Turner, P., Padgham, C., Hedges, A. (eds) Clinical Pharmacology & Therapeutics. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05952-2_21

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