Abstract
The vast literature on dopamine which now exists attests to the pre-eminence it has achieved among the monoamines, since its first recognition as a neurotransmitter in the late 1950’s (Carlsson, 1959). Much of our latter-day interest has been sustained by the finding that L-dopa administration to parkinsonian patients, resulting in dopamine generation in the central nervous system, gives rise to substantial therapeutic benefit (Cotzias et al., 1967). More recently, attention has focussed on the possible role of the amine in schizophrenia (Randrup and Munkvad, 1968). Despite this preoccupation with dopamine, certain metabolic pathways connected with its generation or disposition have still been underinvestigated, particularly in man. This paper sets out to provide a brief evaluation of the importance of four of these pathways in the human brain, L-aromatic amino acid decarboxylase, L-dopa transaminase, monoamine oxidase and phenolsulphotransferase.
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Sandler, M., Glover, V., Reveley, M.A., Lax, P., Rein, G. (1981). Dopamine Metabolism in Human Brain. In: Riederer, P., Usdin, E. (eds) Transmitter Biochemistry of Human Brain Tissue. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05932-4_9
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DOI: https://doi.org/10.1007/978-1-349-05932-4_9
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