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Regulation of 5-HT Receptor Binding as a Biochemical model for Pathological or Functional Changes in the CNS

  • Wolfgang Wesemann
  • Norbert Arold
  • Appletree Rodden
  • Nina Weiner

Abstract

Chemically mediated neurotransmission and the transmitter-receptor interaction depend on the amount of transmitter molecules released as quantal units into the synaptic cleft [Del Castillo and Katz, 1955]. Aside from transmitter concentration also the quality and quantity of receptor molecules will affect the transmission process. Though biochemical in vitro studies are restricted to the characterization of ligand-receptor binding which can supply only limited information about the possible physiological response, the measurement of binding kinetics has proved to be a suitable tool for describing central dysfunctions on the molecular level. After cerebral insult a significant decrease in 5-HT binding was observed in membranes isolated from the infarct region as compared with fractions obtained from intact regions or from control postmortem brain [Weiner et al., 1979]. The possibility that changes in ligand-receptor interaction reflect merely generalized necrosis or postmortem changes seems unlikely in the light of studies on 5-HT binding in Huntington’s chorea [Enna et al., 1976].

Keywords

Tourette Syndrome Receptor Sensitivity Crude Membrane Crude Membrane Fraction Cerebral Insult 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Contributors 1981

Authors and Affiliations

  • Wolfgang Wesemann
    • 1
  • Norbert Arold
    • 1
  • Appletree Rodden
    • 1
  • Nina Weiner
    • 1
  1. 1.Abteilung für Neurochemie, Physiologisch-Chemisches Institut IIPhilipps-UniversitätMarburg/LahnWest Germany

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