Summary
Disturbances of catecholamine metabolism and alterations of other putative neurotransmitters have been demonstrated in both experimental cerebral ischemia and in human stroke. In acute cerebral infarction depletion of dopamine (DA), serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) in both the necrotic and intact brain areas is associated with increase of the 5-HT precursor tryptophan (TRP) and its major metabolite kynurenine (KYN), suggesting increased release and decreased degradation of indoles due to reduced activities of related oxygen dependent enzymes, eg. tyrosine hydroxylase (TH). Specific 5-HT-binding to microsomal membrane fractions obtained from necrotic brain tissue is significantly reduced, but no decrease in binding capacity is found in intact tissue of infarcted brain. In old cerebral infarction reduction of 5-HT and 5-HIAA with slight increase of TRP is seen in the necrotic area, while almost normal levels of 5-HT, 5-HIAA, TRP and KYN in the surrounding scar and intact brain tissue indicate “normalization” of 5-HT and TRP metabolism in the previously ischemic brain.
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References
Anton, A.H., Sayre, D.F. (1964). The distribution of dopamine and dopa in various animals and a method for their determination in diverse biological materials. J.Pharm.exp.Ther. 145, 326–336.
Ashcroft, G.W., Sharman, F.D. (1962). Drug induced changes in the concentration of 5-OR indolyl compounds in the cerebrospinal fluid and caudate nucleus. Brit.J.Pharm. 19, 153–160.
Brown, R.M., Kehr, W., and Carlsson, A. (1975). Functional and biochemical aspects of catecholamine metabolism in brain under hypoxia. Brain Res. 85, 491–509
Bralet, J., Beley, P., Bralet, A.M., Beley A. (1979). Catecholamine levels and turnover during brain ischemia in the rat. J.Neural Transm. 48, 143–155
Calderini C., Carlsson, A., Nordström, C.-H. (1978). Influence of transient ischemia on monoamine metabolism in the rat during oxide and phenobarbitone anesthesia. Brain Res. 157, 303–310
Cvejic, V., Micic, D.V., Djuricic, B.M., Mrsulja, B. J., Mrsulja, B.B. (1980). Monoamines and related enzymes in cerebral cortex and basal ganglia following transient ischemia in gerbils. Acta neuropath. (Berl.) 51, 71–77
Costa, E., Guidotti, A., Živković, B. (1974). Short- and long-term regulation of tyrosine hydroxylase. In Neuropsychopharmacology of Monoamines and their Regulatory Enzymes, (ed. E. Usdin), pp 161–175, Raven Press, New York.
Davis, J.N., Girson, L.T., Jr., Stanton, E., Maury, W. (1979). The effect of hypoxia on brain neurotransmitter systems. Advances in Neurology, Vol 26, 219–223.
Denckla, W.D., Dewey, H.K. (1967). The determination of tryptophan in plasma, liver and urine. J.Lab.clin.Med. 69, 929–934.
Enna, S.J., Bennett, J.P. Jr., Byland, D.D., Creese, I., Burt, D.B., Charness, M.D., Yamamura, H.I., Simatov, R., Snyder, S.N. (1977). Neurotransmitter receptor binding: Regional distribution in human brain. J.Neurochem. 28, 233–236.
Flamm, E.S., Schiffer J., Viau, A.T., Naftchi, N.E. (1978). Alterations of cyclic AMP in cerebral ischemia. Stroke 9, 400–402.
Gaudet, R., Welch, K.M.A., Chabi, E., Wang, T.P. (1978). Effect of transient ischemia on monoamine levels in the cerebral cortex of gerbils. J.Neurochem. 30, 751–757.
Hachinski, V., Shibuya, M., Norris, J.W., Hornykiewicz, O. (1978). Cerebrospinal fluid homovanillic acid in cerebral infarction. J.Neural Transm. Suppl. 14, 45–50.
Hardebo, J.E., Edvinsson, L., Owman, Ch., Svendgaard, N.A. (1978). Potentiation and antagonism of serotonin effects on intracranial and extracranial vessels. Neurology (Minneap.) 28, 64–70.
Harrison, M.J.D., Marsden, C.D., Jenner, P. (1979). Effect of experimental ischemia on neurotransmitter amines in the gerbil brain. Stroke 10, 165–168.
Ishihara, N., Welch, K.M.A., Meyer, J.S., Chabi, E., Naritomi, H., Wang, T.-P.F., Nell, J.H., Hsu, M.-C., Miyakawa Y. (1979). Influence of cerebral embolism on brain monoamines. J.Neurol.Neurosurg. Psychiat. 42, 847–853.
Jellinger, K., Riederer, P., Kothbauer, P. (1978). Changes of some putative neurotransmitters in human cerebral infarction. J.Neural Transm., Suppl. 14, 31–44.
Joseph, M.H., Baker, H.P., Lawson, A.M. (1978). Positive identification of kynurenine in rat and human brain. Biochem.Soc.Trans. 6, 123.
Kobayashi, M., Lust, W.D., and Passonneau, J.V. (1977). Concentrations of energy metabolites and cyclic nucleotides during and after bilateral ischemia in the gerbil cerebral cortex. J.Neurochem. 29, 53–59.
Kogure, K., Scheinberg, P., Kishikawa, H., Busto, H. (1976). The role of monoamines and cyclic AMP in ischemic brain edema. In Dynamics in brain edema, (eds. H.M. Pappius and W. Feindell), pp 203–214. Springer, Berlin-Heidelberg-New York.
Lavyne, M., Moskowitz M.A., Larin, F., Zervas, N., Wurtman, R.J. (1975). Brain 3H-catecholamine metabolism in experimental cerebral ischemia. Neurology (Minneap.) 25, 483–485.
Levy, D.E., Duffy, T.E. (1977). Cerebral energy metabolism during transient ischemia and recovery in the gerbil. J.Neurochem. 28, 63–70.
Ljunggren, B., Brown, K.M. (1975). Monoamine metabolism in rat brain after increased intracranial pressure. In Intracranial pressure II (eds. N. Lundberg, U. Ponten, M. Brock), pp 189–194. Springer, New York-Heidelberg-Berlin.
Lust, W.D., Mrsulja, B.B., Mrsulja, B.J., Passonneau, J.V., Klatzo I. (1975). Putative neurotransmitters and cyclic nucleotides in prolonged ischemia of the cerebral cortex. Brain Res. 98, 394–399.
Lydiard, R.B., Fossom, L.H., Sparber, S.B. (1975). Postnatal evaluation of brain tyrosine hydroxylase activity, without concurrent increase in steady-state catecholamine levels, resulting from dl-alpha-methyl-paratyrosine administration during embryonic development. J.Pharmacol.exp.Therap. 194, 27–36.
McKenzie, E.T., Stewart, M., Young, A.R., Harper, A.M. (1978). Cerebrovascular actions of serotonin. In Advances in Neurology, Vol. 20, (eds. J. Cervos-Navarro et al.) pp 77–83, Raven Press, New York.
McGeer, E.G., Gibson, S., McGeer, P.L. (1967). Some characteristics of brain tyrosine hydroxylase. J.Lab.clin.Med., 69, 929–934.
Meyer, J.S., Okamoto, S., Shimaza, K. (1974). Disordered neurotransmitter function demonstrated by measurement of norepinephrine and 5-hydroxytryptamine in CSF of patients with recent cerebral infarction. Brain 97, 655–664.
Moskowitz, M.A., Wurtman, R.J. (1976). Acute stroke and brain monoamines. In Cerebrovascular diseases (ed. P. Scheinberg), pp 153–166. Raven Press, New York.
Mrsulja, B.B., Lust, W.D., Mrsulja, B.J., Passenneau, J.V. (1977). Effect of repeated cerebral ischemia on metabolites and metabolic rate in gerbil cortex. Brain Res. 119, 480–489.
Mrsulja, B.B., Mrsulja, B.J., Cvejic, V., Djuricic, B.M., Rogad, L. (1978). Alterations of putative neurotransmitters and enzymes during ischemia in gerbil cerebral cortex. J.Neural Transm. Suppl. 14, 23–30.
Mrsulja, B.B., Mrsulja, B.J., Spatz, M., Ito, U., Walker, J.T., Jr., Klatzo, I. (1976). Experimental cerebral ischemia in mongolian gerbils. IV. Behaviour of biogenic amines. Acta neuropath. (Berl.) 36, 1.8
Mrsulja, B.B. (1979). Some new aspects of the pathochemistry of the postischemic period. In Pathophysiology of Cerebral Energy Metabolism (eds. Mrsulja, B.B., Lj.M. Rakic, I. Klatzo, M. Spatz), pp 47–59, Plenum Press, New York — London.
Nakai, K., Welch, K.M.A., Meyer, J.S. (1977). Critical cerebral blood flow after unilateral carotid occlusion in the gerbil. J.Neurosurg.Psychiat. 40, 595–599.
Riederer, P., and Jellinger K., (1979). Brain monoamines in cerebral infarction and coma. In Pathophysiology of Cerebral Energy Metabolism (eds. B.B. Mrsulja, Lj.M. Rakic, I. Klatzo, M. Spatz), pp 121–142, Plenum Press, New York-London.
Siesjö, B.K. (1978). Brain energy metabolism and catecholaminergic activity in hypoxia, hypercapnia and ischemia. J.Neural Transm. Suppl. 14, 17–22.
Vapahlahti, M., Hyyppä, M.T., Nieminen, Y., Rinne, U.K. (1978). Brain monoamine metabolites and tryptophan in ventricular CSF of patients with spasm after aneurism surgery. J.Neurosurg. 48, 58–63.
Weiner, N., Martin, C., Wesemann, W., Riederer, P. (1979). Effects of post-mortem storage on synaptic 5-HT binding and uptake in mammalian brain. J.Neural Transm. 46, 253–262.
Welch, K.M.A., Chabi, E., Buckingham, J., Bergin, B., Achar, V.S., Meyer, J.S. (1977). Catecholamine and 5-HT levels in ischemic brain. Influence of p-chlorophenylalanine. Stroke 8, 341–346.
Welch, K.M.A., Chabi, E., Dodson, R.F., Bergin, B. (1976). The role of biogenic amines in the progression of cerebral ischemia and edema. In Dynamics of Brain Edema (eds. Pappius, H., W. Feindel), pp 193–202, Springer, Berlin-Heidelberg-New York.
Welch, K.M.A., Meyer, J.S., Chee, A.N.C. (1975). Evidence for disordered cyclic AMP metabolism in patients with cerebral infarction. Europ.Neurol. 13, 144–154.
Westergaard, E. (1977). The blood-brain-barrier to horseradish peroxidase under normal and experimental conditions. Acta neuropath. (Berl.) 39, 181–186.
Yanagihara, T. (1976). Cerebral anoxia: effect on neuron-glia fraction and polysomal protein synthesis. J.Neurochem. 27, 537–544.
Zervas, N.T., Lavyne, M.H., Negoro, M. (1975). Neurotransmitters and the normal and ischemic cerebral circulation. New Engl.J.Med. 293, 812–816.
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Jellinger, K., Riederer, P. (1981). Brain Neurotransmitter Amines in Cerebral Ischemia and Stroke. In: Riederer, P., Usdin, E. (eds) Transmitter Biochemistry of Human Brain Tissue. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05932-4_3
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DOI: https://doi.org/10.1007/978-1-349-05932-4_3
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