Biopterin in the Brain of Controls and Patients with Parkinson’s Disease and Related Striatal Degenerative Diseases: Application of New Biopterin Radioimmunoassay
We reported that tyrosine hydroxylase activity in the dopaminergic regions of nigro-striato-pallidal complex of the brain is greatly reduced (5–10% of controls) in all 12 cases of parkinsonian patients (Nagatsu, et al., 1977, 1979). The reduction in tyrosine hydroxylase activity in the parkinsonian brain was also reported by several groups (Lloyd, et al., 1975; McGeer and McGeer, 1976; Riederer, et al., 1979).
KeywordsTyrosine Hydroxylase Caudate Nucleus Parkinsonian Patient Phenylalanine Hydroxylase Tyrosine Hydroxylase Activity
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