Abstract
A great deal of new data on the neurochemistry of human brain has resulted from the availability of post-mortem brain tissues from patients dying from Huntington’s disease (H.D.).
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References
Alzheimer, A. (1911). Huntingtoniche chorea und die choreatishen Bewegungen iberthaupt. Z. Gesamte Neurol. Psychiatr. 3:891–892.
Aquilonius, S.M., Eckernas, S.A. and Sundwall, A. (1975). Regional distribution of choline acetyltransferase in human brain: changes in Huntington’s chorea. J. Neurol. Neurosurg. Psychiatry 38:669–677.
Arregui, A., Iversen, L.L., Spokes, E.G.S. and Emson, P.C. (1979). Alterations in postmortem brain angiotensin-converting enzyme activity and some neuropeptides in Huntington’s disease. In: Advances in Neurology (eds. T.N. Chase, N.S. Wexler and A. Barbeau), Raven Press, New York, 23:517–525.
Barker, J.L. (1976). Peptides: roles in neuronal excitability. Physiol. Rev. 56:435–452.
Bernheimer, H. and Hornykiewicz, O. (1973). Brain amines in Huntington’s chorea. In: Advances in Neurology (eds. A. Barbeau, T.N. Chase and G.W. Paulson), Raven Press, New York, 1:525–531.
Bird, E.D. (1976). Biochemical studies on γ-aminobutyric acid metabolism in Huntington’s chorea. In: Biochemistry and Neurology (eds. H.F. Bradford and C.D. Marsden), Academic Press, London, pp. 83–91.
Bird, E.D. and Iversen, L.L. (1974). Huntington’s chorea: Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransference and dopamine in basal ganglia. Brain 97:457–472.
Bird, E.D., Chiappa, S.A. and Fink, G. (1976). Brain immunoreactive gonadotripin-releasing hormone in Huntington’s chorea and in non-choreic subjects. Nature 260:536–538.
Bird, E.D., Spokes, E.G.S. and Iversen L.L. (1979). Increased dopamine concentration in limbic areas of brain from patients dying with schizophrenia. Brain 102:347–360.
Bowen, D.M., Smith, C.B., White, P. and Davison, A.N. (1976). Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Brain 99:459–496.
Brownstein, M.J., Mroz, E.A., Tappaz, M.L. and Leeman, S.E. (1977). On the origin of substance P and glutamic acid decarboxylase (GAD) in the substantia nigra. Brain Research 135:315–323.
Bruyn, G.W. (1968). Diseases of the basal ganglia. In: Handbook of Clinical Neurology, (eds, P.J. Vinken and G.W. Bruyn), North-Holland Publishing Company, Amsterdam, 6:298–378.
Campbell, A.M.G., Corner, B., Norman, R.M. and Urich, H. (1961). A rigid form of Huntington’s disease. J. Neurol. Neurosurg. Psychiatry 24:71–77.
Chase, T.N. (1973), Biochemical and pharmacological studies of monoamines in Huntington’s chorea. In: Advances in Neurology, (eds. A. Barbeau, T.N. Chase and G.W. Paulson), Raven Press, New York, 1:533–542.
Curzon, G., Gumpert, J. and Sharpe, D. (1972). Amine metabolites in the cerebral spinal fluid in Huntington’s chorea. J. Neurol. Neurosurg. Psychiatry 35:514–519.
Curzon, G. (1975). CSF homovanillic acid: an index of dopaminergic activity. In: Advances in Neurology, (eds. D. Calne, T.N. Chase and A. Barbeau), Raven Press, New York, 9:349–357.
Emson, P.C., Fahrenkrug, J. and Spokes, E.G.S. (1979). Vasoactive intestinal polypeptide (VIP): distribution in normal human brain and in Huntington’s disease. Brain Research, 173:174–178.
Emson, P. et al (1980). Abstract — Transmitter Biochemistry of Human Brain Tissue Symposium, Goteborg, Sweden.
Folstein, S.E., Folstein, M.F. and McHugh, P.R. (1979). Psychiatric syndromes in Huntington’s disease. In: Advances in Neurology, (eds. T.N. Chase, N.S. Wexler and A. Barbeau), Raven Press, New York, 23:281–289.
Gale, J.S., Bird, E.D. Spokes, E.G.S., Iversen, L.L. and Jessell, T. (1978). Human brain substance P: distribution in controls and Huntington’s chorea. J. Neurochem. 30:633–634.
Gibbs, J., Young, R.C. and Smith, G.P. (1973). Cholecystokinin elicits satiety in rats with open gastric fistulas. Nature 245:328–330.
Hokfelt, T., Ljungdahl, A., Steinbusch, H., Verhofstad, A., Nilsson, G., Brodin, E., Pernow, B. and Goldstein, M. (1978), Immunohistochemical evidence of substance-P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system. Neuroscience 3:517–538.
Hokfelt, T. et al (1980). Eur. J. Pharmacol. (submitted).
Hornykiewicz, O. (1963). Die topische Lokalisation und das Verhalten von Noradrenalin und Dopamin (3-hydroxytyramin) in der Stubstantia nigra des normalen und Parksinson-kranken Menschen. Wien. Klin. Wschr. 75:309–312.
Johansson, B. and Roos, B.E. (1975). Concentrations of monoamine metabolites in human lumbar and cisternal cerebrospinal fluid. Acta Neurol. Scand. 52: 137–144.
Kanazawa, I., Miyata, Y., Toyokura, Y. and Otsuka, M. (1973). The distribution of γ-aminobutyric acid (GABA) in the human substantia nigra. Brain Res. 51:363–365.
Kanazawa, E., Bird, E.D., O’Connell, R. and Powell, D. (1977). Evidence for a decrease in substance P content of substantia nigra in Huntington’s chorea. Brain Res. 120:387–392.
Kanazawa, I., Emson, P.C. and Cuello, A.C. (1977). Evidence for the existence of substance P-containing fibres in striato-nigral and pallido-nigral pathways in rat brain. Brain Res. 119:447–453.
Lange, H., Thorner, G., Hopf, A. and Schroder, K.F. (1976). Morphometric studies of the Neuro-pathological changes in choreatic diseases. J. Neurol. Sci. 28:401–425.
Lieberman, A., Dziatolowski, M., Neophytides, A., Kupersmith, M., Aleksic, S., Serby, M., Korein, J. and Goldstein, M. (1979). Dementias of Huntington’s and Parkinson’s disease. In: Advances in Neurology, (eds. T.N. Chase, N.S. Wexler, and A. Barbeau), Raven Press, New York, 23:273–280.
Ljungdahl, A., Hokfelt, T., Nilsson, G. and Goldstein, M. (1978). Distribution of substance P-like immunoreactivity in the central nervous system of the rat-II. Light microscopic localization in relation to catecholamine-containing neurons. Neuroscience 3:945–976.
Manyam, N.J., Hare, T.A., Katz, L. and Glaeser, B.S. (1978). Huntington’s disease. Cerebrospinal fluid GABA levels in at-risk individuals. Arch. Neurol. 35:728–730.
McGeer, P.L. and McGeer, E.G. (1976). Enzymes associated with the metabolism of catecholamines, acetylcholine and GABA in human controls and patients with Parkinson’s disease and Huntington’s chorea. J. Neurochem. 26:65–76.
Okon, E. and Koch, Y. (1976). Nature 263:345–347.
Oliver, J.E. (1970). Huntington’s chorea in Northamptonshire. Br. J. Psychiatry 116:241.
Perry, E.K., Gibson, P.N., Blessed, G., Perry, R.H. and Tomlinson, B.E. (1977). Neurotransmitter enzyme abnormalities in senile dementia. J. Neurol. Sci. 34:247–265.
Perry, T.L., Hansen, S. and Kloster, M. (1973). Huntington’s chorea: deficiency of γ-aminobutyric acid in brain, N. Eng. J. Med. 288:337–342.
Perry, T.L., Buchanan, J., Kish, S.J. and Hansen, S. (1979). γ-aminobutyric acid deficiency in brain of schizophrenic patients. Lancet i:237–239.
Reed, T.E. and Neel, J.V. (1959). Huntington’s chorea in Michigan. II. Selection and mutation. Amer. J. Hum. Genet. II: 107–136.
Rehfeld, J.F. (1978). Immunochemical studies on cholecystokinin. J. Biol. Chem. 253:11, 4022–4030.
Rehfeld, J.F. (1980). Cholecystokinin. Trends in Neuro-Sciences 3:65–67.
Reisine, T.D., Fields, J.Z., Bird, E.D., Spokes, E. and Yamamura, H.I. (1978). Characterization of brain dopaminergic receptors in Huntington’s disease. Commun. Psychopharmac. 2:79–84.
Robberecht, P., Deschodt-Lanckman, M. and Vanderhaeghen, J.J. (1978). Demonstration of biological activity of brain gastrin-like peptidic material in the human: Its relationship with the COOH-terminal octa-peptide of cholecystokinin. Proc. Natl. Acad. Sci. USA 75:1, 524–528.
Spokes, E.G.S., Garrett, N.J. and Iversen, L.L. (1979). Differential effects of agonal status on measurements of GABA and glutamate decarboxylase in human post-mortem brain tissue from control and Huntington’s chorea subjects. J. Neurochem. 33: 773–778.
Spokes, E.G.S. (1980). Neurochemical alterations in Huntington’s chorea — A study of post-mortem brain tissue. Brain 103:179–210.
Tellez-Nagel, I., Johnson, A.B. and Terry, R.D. (1973). Ultrastructural and histochemical study of cerebral biopsies in Huntington’s chorea. In: Advances in Neurology (eds. A. Barbeau, T.N. Chase and G.W. Paulson), Raven Press, New York, 1:387–398.
Vanderhaeghen, J.J., Signeau, J.C. and Gepts, W. (1975). New peptide in the vertebrate CNS reacting with antigastrin antibodies. Nature 257:604–605.
Wallace, D.C. (1974). Huntington’s chorea in Queensland. A not uncommon disease. Med. J. Aust. 39:375.
Wendt, G.G. and Drohm, D. (1972). (Huntington’s chorea. A population-genetic study). In: Humangenetik: Advances in Human Genetics, Theime, Stuttgart, 4:1–121.
Westphal, A. (1905). Case Report, Zbl. Nervenheilk 28:674–675.
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Bird, E.D., Kraus, L.J. (1981). Transmitter Biochemistry of Huntington’s Disease. In: Riederer, P., Usdin, E. (eds) Transmitter Biochemistry of Human Brain Tissue. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05932-4_15
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DOI: https://doi.org/10.1007/978-1-349-05932-4_15
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