A radioreceptor assay for neuroleptic drugs

  • Ian Creese
  • Susan Lader
  • Burton Rosenberg


The routine monitoring of blood levels of drugs such as digoxin, gentamicin, lithium and anticonvulsants has been recognized as a valuable and necessary aid to clinical management. A similar approach to the control of therapy with antipsychotic, neuroleptic drugs has been complicated by (1) the large number of drugs presently in use, (2) their even larger number of active and inactive metabolites, (3) the lack of satisfactory assay procedures, and (4) a general lack of recognition of the toxic effects which may result from high dose levels.


Tardive Dyskinesia Brief Psychiatric Rate Scale Neuroleptic Drug Radioreceptor Assay Fluphenazine Decanoate 
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Copyright information

© The contributors 1981

Authors and Affiliations

  • Ian Creese
    • 1
    • 2
  • Susan Lader
    • 3
  • Burton Rosenberg
    • 4
  1. 1.University of CaliforniaSan DiegoUSA
  2. 2.Department of NeurosciencesSchool of MedicineLa JollaUSA
  3. 3.Wellcome Reagents LimitedKentUK
  4. 4.Burroughs Wellcome CompanyResearch Triangle ParkUSA

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