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The pharmacokinetics and metabolism of tricyclic antidepressant drugs in patients with chronic renal failure

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Clinical Pharmacology in Psychiatry

Abstract

The evaluation and treatment of depression in patients with chronic renal failure (CRF) sometimes presents a difficult clinical problem. Although the appearance of symptoms of depression in such patients is a common occurrence, there is disagreement over the actual incidence of formal primary depressive illness. However, many studies have reported a high incidence of depression and suicide in patients on hospital dialysis treatment (Shea et al., 1965; Retan and Lewis, 1966; Reichsman and Levy, 1972; Cadnapaphornchai et al., 1974). Patients with CRF who are psychiatrically ill have a diminished chance of survival (Farmer et al., 1979); thus the need for effective treatment is particularly pressing.

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Braithwaite, R.A., Dawling, S., Lynn, K., Rosser, R. (1981). The pharmacokinetics and metabolism of tricyclic antidepressant drugs in patients with chronic renal failure. In: Usdin, E., Dahl, S.G., Gram, L.F., Lingjærde, O. (eds) Clinical Pharmacology in Psychiatry. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05929-4_26

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