Haloperidol plasma levels and clinical response in schizophrenia

  • J. Mendlewicz
  • P. Linkowski
  • J. Alexandre
  • A. Schoutens

Abstract

The recent availability of chemical techniques makes it possible to measure plasma levels of psychotropic drugs in relation to clinical response in mental disorders. Although most of the work in this area deals with tricyclic antidepressants, there is a growing interest in pharmacokinetic parameters of antipsychotic medication in schizophrenic illness.

Keywords

Schizophrenia Haloperidol Tricyclic Chlor Nitrazepam 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Jr, Winokur, G. and Munoz, R. (1972). Diagnostic criteria for use in psychiatric research. Archs Gen. Psychiat., 26, 57–63CrossRefGoogle Scholar
  2. Forsman, A. and Öhman, R. (1976). Pharmacokinetic studies of haloperidol in man. Curr. Ther. Res., 20, 319–36PubMedGoogle Scholar
  3. Forsman, A. and Öhman, R. (1977). Applied pharmacokinetics of haloperidol in man. Curr. Ther. Res., 21, 396–411Google Scholar
  4. McCreadie, R. and McDonald, I. (1977). High dosage haloperidol in chronic schizophrenia. Br. J. Psychiat., 131, 310–6CrossRefGoogle Scholar
  5. Morselli, P. L., Bianchetti, G., Durand, G., Le Heuzey, M. F., Zarifian, E. and Dugas, M. (1979). Haloperidol plasma level monitoring in pediatric patients. Ther. Drug Monitor., 1, 35–46CrossRefGoogle Scholar
  6. Tune, L. E., Creese, I., De Paulo, R., Slavney, P. R., Coyle, J. T. and Snyder, S. H. (1980). Clinical state and serum neuroleptic levels measured by radioreceptor assay in schizophrenia. Am. J. Psychiat., 137, 187–90PubMedCrossRefGoogle Scholar

Copyright information

© The contributors 1981

Authors and Affiliations

  • J. Mendlewicz
    • 1
  • P. Linkowski
    • 1
  • J. Alexandre
    • 1
  • A. Schoutens
    • 1
  1. 1.Department of Psychiatry and Department of Nuclear Medicine, Erasme HospitalFree University of BrusselsBrusselsBelgium

Personalised recommendations