Abstract
Every time the clinical significance of neuroleptic plasma level monitoring is discussed in congresses or seminars, two opposite opinions are encountered. On the one side, there are physicians and scientists who think that neuroleptic plasma level monitoring is only an interesting, but expensive, intellectual exercise which has very little to do with the treatment or the management of the psychotic patient; on the other side, there are physicians and scientists who believe that neuroleptic plasma level monitoring may be a useful tool for a more rational and safer therapeutic approach to psychiatry. Such a situation has apparently crystallized for at least six years, with no real dialogue between the two parties and a growing scepticism towards the possible value of therapeutic drug monitoring in psychiatry, as documented by a recent editorial (Editorial, 1979). This fact is highly regrettable because the field of neuroleptics appears as the only one which has not yet taken advantage of the increased knowledge on drug utilization and prescription brought about by the development of clinical pharmacology.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bjørndal, N., Bjeere, M., Gerlach, J., Kristiansen, P., Magelund, G., Destrich, I N. and Waehrens, J. (1980). High dosage haloperidol therapy in chronic schizophrenic patients: a double-blind study of clinical response, side effects, serum haloperidol and serum prolactin. Psychopharmacology, 67,17–23
Casper, R., Garver, D. L., Dekirmenjian, H., Chang, S. and Davis, J. M. (1980). Phenothiazine levels in plasma and red blood cells — their relationship to clinical improvement in schizophrenia. Archs gen. Psychiat., 37, 301–5
Dahl, S. G. (1979). Monitoring of phenothiazine plasma levels in psychiatric patients. In Neuropsychopharmacology (ed. B. Saletu, P. Berner and L. Hollister), Pergamon Press, Oxford, pp. 567–75
Editorial (1979). Monitoring plasma concentrations of psychotropic drugs. Br. med. J., ii, 513–4
Forsman, A. and Ohman, R. (1979). Pharmacokinetics and pharmacodynamics of haloperidol in man. In Neuropsychopharmacology (ed. B. Saletu, P. Berner and L. Hollister), Pergamon Press, Oxford, pp. 559–65
Gelder, M. and Kolakowska, T. (1979). Variability of response to neuroleptics in schizophrenia: clinical, pharmacologic and neuroendocrine correlates. Compr. Psychiat., 20, 397–408
McCreadie, R. G., Flanagan, W. L., McKnight, J. and Jorgensen (1979). High dose flupenthixol decanoate in chronic schizophrenia. Br. J. Psychiat., 135, 175–9
Meyers, B., Tune, L. E. and Coyle, J. T. (1980). Clinical response and serum neuroleptic levels in childhood schizophrenia. Am. J. Psychiat., 137, 483–4
Morselli, P. L. (1976). Pediatric clinical pharmacology. Routine monitoring or clinical trials? In Clinical Pharmacology and Clinical Pharmacy (ed. B. Gouveia, G. Tognoni and E. Van Der Kleijn), Elsevier/North Holland, Amsterdam, pp. 277–87
Morselli, P. L. (1977). Drug Disposition During Development, Spectrum Publ. Inc., New York
Morselli, P. L. (1978). Clinical significance of monitoring plasma levels of benzodiazepine tranquilizers and antiepileptic drugs. In Neuropsychopharmacology (ed. P. Deniker, C. Radouco-Thomas and A. Villeneuve), Pergamon Press, Oxford, pp. 877–88
Morselli, P. L. (1979). Biological monitoring of psychotropic drugs treatment. Chairman’s introductory remarks. Neuropsychopharmacology (ed. B. Saletu, P. Berner and L. Hollister), Pergamon Press, Oxford, pp. 555–8
Morselli, P. L. and Zarifian, E. (1980). Clinical significance of monitoring plasma levels of psychotropic drugs. In Drug Concentrations in Neuropsychiatry, Ciba Foundation Symposium 74, pp. 115–128
Morselli, P. L., Cuche, H. and Zarifian, E. (1978). Pharmacokinetics of psychotropic drugs in the pediatric patient. Adv. biol. Psychiat., 2, 70–86
Morselli, P. L., Bianchetti, G., Durand, G., Le Heuzey, M. F., Zarifian, E. and Dugas, M. (1979). Haloperidol plasma levels monitoring in pediatric patients. Ther. Drug Monitor., 1, 35–46
Morselli, P. L., Franco-Morselli, R. and Bossi, L. (1980a). Clinical pharmacokinetics in newborns and infants (age related differences and therapeutic implications). Clin. Pharmacokinet., in press
Morselli, P. L., Zarifian, E., Cuche, H., Bianchetti, G., Cottereau, M. J. and Deniker, P. (1980b). Haloperidol plasma levels monitoring in psychiatric patients. In Long Term Effects of Neuroleptics(ed. F. Cattabeni and G. Raccagni), Raven Press, New York, in press
Rivera-Calimlim, L., Gift, T., Nasrallah, H. A., Wyatt, R. J., and Lasagna, L. (1978). Correlation between plasma concentrations of chlorpromazine and clinical response. Commun. Psychopharmac., 2, 215–22
Rivera-Calimlim, L., Griesbach, P. H. and Perlmutter, R. (1979). Plasma chlorpromazine concentrations in children with behavioral disorders and mental illness. Clin. Pharmac. Ther., 26, 114–21
Smith, R. C, Crayton, J., Dekirmenjian, H., Klass, D. and Davis, J. M. (1979). Blood levels of neuroleptic drugs in nonresponding chronic schizophrenic patients. Archs gen. Psychiat., 36, 579–84
Tune, L. and Coyle, J. T. (1980). Serum levels of anticholinergic drugs in the treatment of acute extrapyramidal side effects. Archs gen. Psychiat., 37, 293–7
Tune, L. E., Creese, I., Depaulo, J. R., Slavney, P. R., Coyle, J. T. and Snyder, S. (1980). Clinical state and serum neuroleptic levels measured by radioreceptor assay in schizophrenia. Am. J. Psychiat., 137, 187–90
Wode-Helgodt, B., Borg, S., Fyro, B. and Sedvall, G. (1978). Clinical effects and drug concentrations in plasma and cerebrospinal fluid in psychotic patients treated with fixed doses of chlorpromazine. Acta psychiat. scand., 58, 149–73
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1981 The contributors
About this chapter
Cite this chapter
Morselli, P.L. (1981). Clinical significance of neuroleptic plasma level monitoring. In: Usdin, E., Dahl, S.G., Gram, L.F., Lingjærde, O. (eds) Clinical Pharmacology in Psychiatry. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05929-4_17
Download citation
DOI: https://doi.org/10.1007/978-1-349-05929-4_17
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-05931-7
Online ISBN: 978-1-349-05929-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)