Abstract
When Curry in 1968 published his first gas chromatographic method for the determination of chlorpromazine (Curry, 1968) many expected therapeutic monitoring of this drug to be just around the corner. Since then 12 years have elapsed, characterized by an enormous advance in analytical possibilities, but without much progress when evaluated from a clinical aspect (Cooper, 1978; May and Van Putten, 1978); some possible reasons for this will be sought. The present paper is divided into two main parts: first, general considerations concerning some practical and pharmacokinetic items; second, a review of six different analytical methods, including both their advantages and problems, evaluated from a clinical point of view.
Keywords
- High Performance Liquid Chromatography
- Parent Compound
- Therapeutic Monitoring
- Plasma Concentration Profile
- Fluphenazine Decanoate
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aaes-Jørgensen, T. (1980). A specific high performance liquid chromatographic method for estimation of the cis-(Z)- and trans-(E)-isomers of clopentixol and a N-dealkyl metabolite. J. Chromatogr., in press
Chan, T. L. and Gershon, S. (1973). Chlorpromazine metabolism in humans. Mikrochim. Acta, 435–52
Cooper, S., Albert, J.-M., Dugal, R., Bertrand, M. and Elic, R. (1979). Gas chromatographic determination of amitriptyline, nortriptyline and perphenazine in plasma of schizophrenic patients after administration of the combination of amitriptyline. Arzneim. Forsch., 29, 158–61
Cooper, T. B. (1978). Plasma level monitoring of antipsychotic drugs. Clin. Pharmacokinet., 3, 14–38
Creese, I. and Snyder, S. H. (1977). A simple and sensitive radio receptor assay for antischizophrenic drugs in blood. Nature, Lond. 270, 180–2
Curry, S. H. (1968). Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma using gas-liquid chromatography with an electron capture detector. Analyt. Chem., 40, 1251–5
Fredericson Overø, K. (1980). A specific fluorimetric method for assay of drug in serum of patients treated with clopenthixol decanoate injections. Acta psychiat. scand., in press
Hammer, C.-G., Holmstedt, B. and Ryhage, R. (1968). Mass fragmentography. Identification of chlorpromazine and its metabolites in human blood by a new method. Analyt. Biochem., 25, 532–48
Hobbs, D. C., Welch, W. M., Short, M. J., Moody, W. A. and Ver Der Weide, C. D. (1974). Pharmacokinetics of thiothixene in man. Clin. Pharmac. Ther., 16, 473–8
Jørgensen, A. (1978). A sensitive and specific radioimmunoassay for cis-(Z)-flupenthixol in human serum. Life Sci., 23, 1533–42
Larsen, N.-E. and Næstoft, J. (1975). Determination of perphenazine and its sulphoxide metabolite in human plasma using gas liquid chromatography. J. Chromatogr., 109, 359–64
May, R. A. and Van Putten, T. (1978). Plasma levels of chlorpromazine in schizophrenia. Archs gen. Psychiat., 35, 1081–7
Robinson, J. D. and Risby, D. (1977). Radioimmunoassay for flupenthixol in plasma. Clin. Chem., 23, 2085–8
Tune, L. E., Creese, I., Coyle, J. T., Pearlson, G. and Snyder, S. H. (1980). Low neuroleptic serum levels in patients receiving fluphenazine decanoate. Am. J. Psychiat., 137, 80–2
Wiles, D. H. and Franklin, M. (1978). Radioimmunoassay for fluphenazine in human plasma. Br. J. clin. Pharmac., 5, 265–8
Zingales, I. A. (1969). Detection of chlorpromazine and thioridazine metabolites in human erythrocytes. J. Chromatogr., 44, 547–62
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1981 The contributors
About this chapter
Cite this chapter
Larsen, NE. (1981). Evaluation of existing methods for quantitation of neuroleptics in relation to clinical use. In: Usdin, E., Dahl, S.G., Gram, L.F., Lingjærde, O. (eds) Clinical Pharmacology in Psychiatry. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05929-4_1
Download citation
DOI: https://doi.org/10.1007/978-1-349-05929-4_1
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-05931-7
Online ISBN: 978-1-349-05929-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)