Abstract
Using a recently developed capacitance-minimisation-potential technique (Schoch et al., 1979a), a quite unexpected interaction between adrenocorticotrophin-(1-24)-tetrakosipeptide (ACTH1-24) and artificial planar lipid-bilayer membranes was revealed. After addition of ACTH1-24 to one side of the pure lipid membrane, the hormone molecules are adsorbed in a rapid, reversible reaction, whereupon, in a slow reaction, parts of the individual molecules, presumably their N-termini, become exposed to the aqueous solution on the opposite side (Schoch et al., 1979b; see figure 12.1).
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© 1981 Institute of Biology Endowment Trust Fund
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Schwyzer, R., Fischli, W., Gysin, B., Sargent, D.F., Schoch, P. (1981). Adrenocorticotrophin-(1-24)-tetrakosipeptide spans lipid membranes: experiments with liposomes. In: Birdsall, N.J.M. (eds) Drug Receptors and Their Effectors. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-05555-5_12
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DOI: https://doi.org/10.1007/978-1-349-05555-5_12
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