Methods for Assessment of the Effect of Drugs on Cerebral Blood Flow in Man

  • I. M. James


The importance of separately considering the effect of any drug on the cerebral as opposed to the rest of the circulation should really need no emphasis. Although the brain represents only 2% of the body mass it has a blood supply of 15% of the resting cardiac output, and utilises nearly a quarter of the body’s total oxygen requirements at rest (Folkow & Neil, 1971). Even small regional changes in flow can result in catastrophic clinical sequelae.


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Copyright information

© Macmillan Publishers Limited 1980

Authors and Affiliations

  • I. M. James
    • 1
  1. 1.Section of Clinical Pharmacology, Academic Department of MedicineRoyal Free HospitalLondonUK

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